Basic reactions of osteoblasts on structured material surfaces
In order to assess how bone substitute materials determine bone formation in vivo it is useful to understand the mechanisms of the material surface/tissue interaction on a cellular level. Artificial materials are used in two applications, as biomaterials alone or as a scaffold for osteoblasts in a t...
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AO Research Institute Davos
2005-04-01
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Online Access: | http://www.ecmjournal.org/papers/vol009/pdf/v009a06.pdf |
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doaj-0690b8ad14a54188b5f0673937a301162020-11-24T22:36:30Zeng AO Research Institute DavosEuropean Cells & Materials1473-22622005-04-019394910.22203/eCM.v009a06Basic reactions of osteoblasts on structured material surfacesU. Meyer0A. BüchterH.P. WiesmannU. Joos D.B. JonesDepartment of Cranio-Maxillofacial Surgery, University of Münster, Waldeyerstr. 30, D-48149 Münster. GermanyIn order to assess how bone substitute materials determine bone formation in vivo it is useful to understand the mechanisms of the material surface/tissue interaction on a cellular level. Artificial materials are used in two applications, as biomaterials alone or as a scaffold for osteoblasts in a tissue engineering approach. Recently, many efforts have been undertaken to improve bone regeneration by the use of structured material surfaces. In vitro studies of bone cell responses to artificial materials are the basic tool to determine these interactions. Surface properties of materials surfaces as well as biophysical constraints at the biomaterial surface are of major importance since these features will direct the cell responses. Studies on osteoblast-like cell reactivity towards materials will have to focus on the different steps of protein and cell reactions towards defined surface properties. The introduction of new techniques allows nowadays the fabrication of materials with ordered surface structures. This paper gives a review of present knowledge on the various stages of osteoblast reactions on material surfaces, focused on basic cell events under in vitro conditions. Special emphasis is given to cellular reactions towards ordered nano-sized topographies. http://www.ecmjournal.org/papers/vol009/pdf/v009a06.pdfBiomaterialstissue engineeringosteoblastscell culture |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
U. Meyer A. Büchter H.P. Wiesmann U. Joos D.B. Jones |
spellingShingle |
U. Meyer A. Büchter H.P. Wiesmann U. Joos D.B. Jones Basic reactions of osteoblasts on structured material surfaces European Cells & Materials Biomaterials tissue engineering osteoblasts cell culture |
author_facet |
U. Meyer A. Büchter H.P. Wiesmann U. Joos D.B. Jones |
author_sort |
U. Meyer |
title |
Basic reactions of osteoblasts on structured material surfaces |
title_short |
Basic reactions of osteoblasts on structured material surfaces |
title_full |
Basic reactions of osteoblasts on structured material surfaces |
title_fullStr |
Basic reactions of osteoblasts on structured material surfaces |
title_full_unstemmed |
Basic reactions of osteoblasts on structured material surfaces |
title_sort |
basic reactions of osteoblasts on structured material surfaces |
publisher |
AO Research Institute Davos |
series |
European Cells & Materials |
issn |
1473-2262 |
publishDate |
2005-04-01 |
description |
In order to assess how bone substitute materials determine bone formation in vivo it is useful to understand the mechanisms of the material surface/tissue interaction on a cellular level. Artificial materials are used in two applications, as biomaterials alone or as a scaffold for osteoblasts in a tissue engineering approach. Recently, many efforts have been undertaken to improve bone regeneration by the use of structured material surfaces. In vitro studies of bone cell responses to artificial materials are the basic tool to determine these interactions. Surface properties of materials surfaces as well as biophysical constraints at the biomaterial surface are of major importance since these
features will direct the cell responses. Studies on osteoblast-like cell reactivity towards materials will have to focus on the different steps of protein and cell reactions towards defined surface properties. The introduction of new techniques allows nowadays the fabrication of materials with ordered surface structures. This paper gives a review of present knowledge on the various stages of osteoblast reactions on material surfaces, focused on basic cell events under in vitro conditions. Special emphasis is given to
cellular reactions towards ordered nano-sized topographies.
|
topic |
Biomaterials tissue engineering osteoblasts cell culture |
url |
http://www.ecmjournal.org/papers/vol009/pdf/v009a06.pdf |
work_keys_str_mv |
AT umeyer basicreactionsofosteoblastsonstructuredmaterialsurfaces AT abuchter basicreactionsofosteoblastsonstructuredmaterialsurfaces AT hpwiesmann basicreactionsofosteoblastsonstructuredmaterialsurfaces AT ujoos basicreactionsofosteoblastsonstructuredmaterialsurfaces AT dbjones basicreactionsofosteoblastsonstructuredmaterialsurfaces |
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