Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization
Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotic...
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doaj-0690f18f7c6547f79e95d3898fc75ecc2020-11-24T23:29:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122014-05-01510.3389/fphar.2014.0010589549Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages UtilizationSanti M. Mandal0Ananta K Ghosh1Anupam eRoy2Tapas eHazra3Amit eBasak4Octavio Luiz Franco5Indian Institute of Technology KharagpurIndian Institute of Technology KharagpurIndian Institute of Technology KharagpurUniversity of Texas Medical BranchIndian Institute of Technology KharagpurUniversidade Catolica de BrasiliaBacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, LPS and efflux pump inhibitors to control the infections caused by MDR pathogens.http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00105/fullBacterial InfectionsInfection Controlantibioticsantimicrobial peptidesmulti-drug-resistant pathogens |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Santi M. Mandal Ananta K Ghosh Anupam eRoy Tapas eHazra Amit eBasak Octavio Luiz Franco |
spellingShingle |
Santi M. Mandal Ananta K Ghosh Anupam eRoy Tapas eHazra Amit eBasak Octavio Luiz Franco Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization Frontiers in Pharmacology Bacterial Infections Infection Control antibiotics antimicrobial peptides multi-drug-resistant pathogens |
author_facet |
Santi M. Mandal Ananta K Ghosh Anupam eRoy Tapas eHazra Amit eBasak Octavio Luiz Franco |
author_sort |
Santi M. Mandal |
title |
Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization |
title_short |
Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization |
title_full |
Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization |
title_fullStr |
Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization |
title_full_unstemmed |
Challenges and Future Prospects of Antibiotic Therapy: From Peptides to Phages Utilization |
title_sort |
challenges and future prospects of antibiotic therapy: from peptides to phages utilization |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2014-05-01 |
description |
Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, LPS and efflux pump inhibitors to control the infections caused by MDR pathogens. |
topic |
Bacterial Infections Infection Control antibiotics antimicrobial peptides multi-drug-resistant pathogens |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00105/full |
work_keys_str_mv |
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