The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis

The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis

TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of IFN-induced long non-coding RNAs (lncRNAs) that feed-back regulate the IFN response have been identified. Dysregulation of this process, col...

Full description

Bibliographic Details
Main Authors: Barbara Mariotti, Nila Hendrika Servaas, Marzia Rossato, Nicola Tamassia, Marco A. Cassatella, Marta Cossu, Lorenzo Beretta, Maarten van der Kroef, Timothy R. D. J. Radstake, Flavia Bazzoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
long non-coding RNAs
monocytes
systemic sclerosis
interferon
NRIR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00100/full

Similar Items

Similar Items