Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age
Abstract Background Aim of the study is to intercept specific characteristics and psychiatric comorbidity in Down Syndrome (DS). The study describes the distribution and the age of specific aspects of behavioral phenotype in a sample of subjects with DS. Methods Psychopathological risk has been eval...
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doaj-06940afb515c43cd807a33c63cb2b9582020-11-25T03:32:07ZengBMCItalian Journal of Pediatrics1824-72882019-07-014511510.1186/s13052-019-0672-4Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental ageM. Marino0I. Scala1O. Scicolone2P. Strisciuglio3C. Bravaccio4Department of Medical and Translational Science, Federico II University HospitalDepartment of Medical and Translational Science, Federico II University HospitalDepartment of Medical and Translational Science, Federico II University HospitalDepartment of Medical and Translational Science, Federico II University HospitalDepartment of Medical and Translational Science, Federico II University HospitalAbstract Background Aim of the study is to intercept specific characteristics and psychiatric comorbidity in Down Syndrome (DS). The study describes the distribution and the age of specific aspects of behavioral phenotype in a sample of subjects with DS. Methods Psychopathological risk has been evaluated in a 97 DS patient cohort, aged 1 to 18 years, during regular follow-up neuropsychiatric visit and through administration of Child Behavior Checklist (CBCL); Childhood Autism Rating Scale (CARS-T) was assessed to verify the presence of autistic behaviors. Results The results show the presence of specific psychopathological risk factors in 90% of the sample. 7% of sample presents autistic features. The risk of psychopathology is independent of the degree of intellectual disability. Conclusion The high frequency of psychopathological risk factors indicates the need for accurate monitoring to intercept specific characteristics, such as in the case of comorbidity for autism. The search for specific psychopathological factors is a little explored aspect to date, as evidenced by the literature. Despite the studies available to date highlight the presence of psychopathological vulnerability in DS, so far there are only few reports that explore this issue systematically.http://link.springer.com/article/10.1186/s13052-019-0672-4Attention deficit/hyperactive disorderAutism Spectrum disorderDown syndromeOppositional defiant disorder;psychopathological risk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Marino I. Scala O. Scicolone P. Strisciuglio C. Bravaccio |
spellingShingle |
M. Marino I. Scala O. Scicolone P. Strisciuglio C. Bravaccio Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age Italian Journal of Pediatrics Attention deficit/hyperactive disorder Autism Spectrum disorder Down syndrome Oppositional defiant disorder;psychopathological risk |
author_facet |
M. Marino I. Scala O. Scicolone P. Strisciuglio C. Bravaccio |
author_sort |
M. Marino |
title |
Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age |
title_short |
Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age |
title_full |
Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age |
title_fullStr |
Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age |
title_full_unstemmed |
Distribution and age of onset of psychopathological risk in a cohort of children with Down syndrome in developmental age |
title_sort |
distribution and age of onset of psychopathological risk in a cohort of children with down syndrome in developmental age |
publisher |
BMC |
series |
Italian Journal of Pediatrics |
issn |
1824-7288 |
publishDate |
2019-07-01 |
description |
Abstract Background Aim of the study is to intercept specific characteristics and psychiatric comorbidity in Down Syndrome (DS). The study describes the distribution and the age of specific aspects of behavioral phenotype in a sample of subjects with DS. Methods Psychopathological risk has been evaluated in a 97 DS patient cohort, aged 1 to 18 years, during regular follow-up neuropsychiatric visit and through administration of Child Behavior Checklist (CBCL); Childhood Autism Rating Scale (CARS-T) was assessed to verify the presence of autistic behaviors. Results The results show the presence of specific psychopathological risk factors in 90% of the sample. 7% of sample presents autistic features. The risk of psychopathology is independent of the degree of intellectual disability. Conclusion The high frequency of psychopathological risk factors indicates the need for accurate monitoring to intercept specific characteristics, such as in the case of comorbidity for autism. The search for specific psychopathological factors is a little explored aspect to date, as evidenced by the literature. Despite the studies available to date highlight the presence of psychopathological vulnerability in DS, so far there are only few reports that explore this issue systematically. |
topic |
Attention deficit/hyperactive disorder Autism Spectrum disorder Down syndrome Oppositional defiant disorder;psychopathological risk |
url |
http://link.springer.com/article/10.1186/s13052-019-0672-4 |
work_keys_str_mv |
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1724569565736730624 |