The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients

<p>Abstract</p> <p>Background</p> <p>Cirrhotic patients are characterized by a decreased synthesis of coagulation and anticoagulation factors. The coagulopathy of cirrhotic patients is considered to be auto-anticoagulation. Our aim was to determine the incidence and pre...

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Bibliographic Details
Main Authors: Alqahtani Saad, Aldorzi Hasan, Rishu Asgar, Alsaadi Alawi, Aljumah Abdulrahman, Arabi Yaseen, Aldawood Abdulaziz, Alsultan Mohammad, Felemban Afaf
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Thrombosis Journal
Online Access:http://www.thrombosisjournal.com/content/9/1/1
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Summary:<p>Abstract</p> <p>Background</p> <p>Cirrhotic patients are characterized by a decreased synthesis of coagulation and anticoagulation factors. The coagulopathy of cirrhotic patients is considered to be auto-anticoagulation. Our aim was to determine the incidence and predictors of venous thromboembolism (VTE) and examine the practice of deep venous thrombosis (DVT) prophylaxis among hospitalized cirrhotic patients.</p> <p>Methods</p> <p>A retrospective cohort study was performed in a tertiary teaching hospital. We included all adult patients admitted to the hospital with a diagnosis of liver cirrhosis from January 1, 2009 to December 31, 2009. We grouped our cohort patients in two groups, cirrhotic patients without VTE and cirrhotic with VTE.</p> <p>Results</p> <p>Over one year, we included 226 cirrhotic patients, and the characteristics of both groups were similar regarding their clinical and laboratory parameters and their outcomes. Six patients (2.7%) developed VTE, and all of the VTEs were DVT. Hepatitis C was the most common (51%) underlying cause of liver cirrhosis, followed by hepatitis B (22%); 76% of the cirrhotic patients received neither pharmacological nor mechanical DVT prophylaxis.</p> <p>Conclusion</p> <p>Cirrhotic patients are at risk for developing VTE. The utilization of DVT prophylaxis was suboptimal.</p>
ISSN:1477-9560