Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure
Objective. To determine early predictors of outcomes of adult patients with severe acute respiratory failure. Method. 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SO...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | The Scientific World Journal |
Online Access: | http://dx.doi.org/10.1155/2013/413216 |
id |
doaj-069527b728dc4b7b9761cdb63c5b92e2 |
---|---|
record_format |
Article |
spelling |
doaj-069527b728dc4b7b9761cdb63c5b92e22020-11-24T22:01:08ZengHindawi LimitedThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/413216413216Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory FailureHsu-Ching Kao0Ting-Yu Lai1Heui-Ling Hung2Yu-Mu Chen3Po-An Chou4Chin-Chou Wang5Meng-Chih Lin6Wen-Feng Fang7Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDepartment of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Niaosung, Kaohsiung 833, TaiwanObjective. To determine early predictors of outcomes of adult patients with severe acute respiratory failure. Method. 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SOFA) score, Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) score, PaO2, FiO2, PaO2/FiO2, PEEP, mean airway pressure (mPaw), and oxygenation index (OI) on the 1st and the 3rd day of mechanical ventilation, and change in OI within 3 days were recorded. Primary outcome was hospital mortality; secondary outcome measure was ventilator weaning failure. Results. 38 out of 100 (38%) patients died within the study period. 48 patients (48%) failed to wean from ventilator. Multivariate analysis showed day 3 OI () and SOFA () score were independent predictors of hospital mortality. Preexisting cerebrovascular accident (CVA) () was the predictor of weaning failure. Results from Kaplan-Meier method demonstrated that higher day 3 OI was associated with shorter survival time (log-Rank test, ). Conclusion. Early OI (within 3 days) and SOFA score were predictors of mortality in severe acute respiratory failure. In the future, prospective studies measuring serial OIs in a larger scale of study cohort is required to further consolidate our findings.http://dx.doi.org/10.1155/2013/413216 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hsu-Ching Kao Ting-Yu Lai Heui-Ling Hung Yu-Mu Chen Po-An Chou Chin-Chou Wang Meng-Chih Lin Wen-Feng Fang |
spellingShingle |
Hsu-Ching Kao Ting-Yu Lai Heui-Ling Hung Yu-Mu Chen Po-An Chou Chin-Chou Wang Meng-Chih Lin Wen-Feng Fang Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure The Scientific World Journal |
author_facet |
Hsu-Ching Kao Ting-Yu Lai Heui-Ling Hung Yu-Mu Chen Po-An Chou Chin-Chou Wang Meng-Chih Lin Wen-Feng Fang |
author_sort |
Hsu-Ching Kao |
title |
Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure |
title_short |
Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure |
title_full |
Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure |
title_fullStr |
Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure |
title_full_unstemmed |
Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure |
title_sort |
sequential oxygenation index and organ dysfunction assessment within the first 3 days of mechanical ventilation predict the outcome of adult patients with severe acute respiratory failure |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
1537-744X |
publishDate |
2013-01-01 |
description |
Objective. To determine early predictors of outcomes of adult patients with severe acute respiratory failure. Method. 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SOFA) score, Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) score, PaO2, FiO2, PaO2/FiO2, PEEP, mean airway pressure (mPaw), and oxygenation index (OI) on the 1st and the 3rd day of mechanical ventilation, and change in OI within 3 days were recorded. Primary outcome was hospital mortality; secondary outcome measure was ventilator weaning failure. Results. 38 out of 100 (38%) patients died within the study period. 48 patients (48%) failed to wean from ventilator. Multivariate analysis showed day 3 OI () and SOFA () score were independent predictors of hospital mortality. Preexisting cerebrovascular accident (CVA) () was the predictor of weaning failure. Results from Kaplan-Meier method demonstrated that higher day 3 OI was associated with shorter survival time (log-Rank test, ). Conclusion. Early OI (within 3 days) and SOFA score were predictors of mortality in severe acute respiratory failure. In the future, prospective studies measuring serial OIs in a larger scale of study cohort is required to further consolidate our findings. |
url |
http://dx.doi.org/10.1155/2013/413216 |
work_keys_str_mv |
AT hsuchingkao sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT tingyulai sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT heuilinghung sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT yumuchen sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT poanchou sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT chinchouwang sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT mengchihlin sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure AT wenfengfang sequentialoxygenationindexandorgandysfunctionassessmentwithinthefirst3daysofmechanicalventilationpredicttheoutcomeofadultpatientswithsevereacuterespiratoryfailure |
_version_ |
1725841542514475008 |