A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs

Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR...

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Main Authors: Fatemeh Farjadian, Soha Azadi, Soliman Mohammadi-Samani, Hajar Ashrafi, Amir Azadi
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018355488
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spelling doaj-0695e7a0d74b41d7bb9c4580882b6bf52020-11-25T03:16:55ZengElsevierHeliyon2405-84402018-11-01411e00930A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugsFatemeh Farjadian0Soha Azadi1Soliman Mohammadi-Samani2Hajar Ashrafi3Amir Azadi4Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author.Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author.Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR spectrum confirmed the presence of amine group and CHN analysis determined the amount of organic layer. The high surface area (750 m2/g) was determined by applying nitrogen adsorption-desorption technique. The morphology was examined by scanning electron microscopy which proved hexagonal structure. The crystallinity of mesoporous material was observed in XRD pattern of this material. According to previous background of such material in adsorbing drug, herein, the efficiency of this material in adsorbing of 5-fluorouracil was evaluated through solid phase extraction method in aqueous and plasma media with high performance liquid chromatography. The extraction efficiency was evaluated for drug concentrations of 500–2000 ng/ml by means of 5–20 mg/ml hexagonal mesoporous silica in both media. The results showed good to excellent recovery rate of in both aqueous and plasma medium which confirmed that the aminopropyl functionalized hexagonal mesoporous silica could be considered as promising device for drug bioanalysis.http://www.sciencedirect.com/science/article/pii/S2405844018355488Pharmaceutical scienceMaterials chemistryPharmaceutical chemistry
collection DOAJ
language English
format Article
sources DOAJ
author Fatemeh Farjadian
Soha Azadi
Soliman Mohammadi-Samani
Hajar Ashrafi
Amir Azadi
spellingShingle Fatemeh Farjadian
Soha Azadi
Soliman Mohammadi-Samani
Hajar Ashrafi
Amir Azadi
A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
Heliyon
Pharmaceutical science
Materials chemistry
Pharmaceutical chemistry
author_facet Fatemeh Farjadian
Soha Azadi
Soliman Mohammadi-Samani
Hajar Ashrafi
Amir Azadi
author_sort Fatemeh Farjadian
title A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_short A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_full A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_fullStr A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_full_unstemmed A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_sort novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
publisher Elsevier
series Heliyon
issn 2405-8440
publishDate 2018-11-01
description Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR spectrum confirmed the presence of amine group and CHN analysis determined the amount of organic layer. The high surface area (750 m2/g) was determined by applying nitrogen adsorption-desorption technique. The morphology was examined by scanning electron microscopy which proved hexagonal structure. The crystallinity of mesoporous material was observed in XRD pattern of this material. According to previous background of such material in adsorbing drug, herein, the efficiency of this material in adsorbing of 5-fluorouracil was evaluated through solid phase extraction method in aqueous and plasma media with high performance liquid chromatography. The extraction efficiency was evaluated for drug concentrations of 500–2000 ng/ml by means of 5–20 mg/ml hexagonal mesoporous silica in both media. The results showed good to excellent recovery rate of in both aqueous and plasma medium which confirmed that the aminopropyl functionalized hexagonal mesoporous silica could be considered as promising device for drug bioanalysis.
topic Pharmaceutical science
Materials chemistry
Pharmaceutical chemistry
url http://www.sciencedirect.com/science/article/pii/S2405844018355488
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