Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice.
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation. Moreover, increasing evidence suggests that neuroinflammation plays a pivotal role in the development of Niemann-Pick type C (...
Main Authors: | Pablo J Sáez, Juan A Orellana, Natalia Vega-Riveros, Vania A Figueroa, Diego E Hernández, Juan F Castro, Andrés D Klein, Jean X Jiang, Silvana Zanlungo, Juan C Sáez |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3744576?pdf=render |
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