Ovarian Cancer Stem Cells: A New Target for Cancer Therapy
Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due t...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2013/916819 |
id |
doaj-06a17ae4430e44c1b88c7be6a52524ea |
---|---|
record_format |
Article |
spelling |
doaj-06a17ae4430e44c1b88c7be6a52524ea2020-11-24T21:24:35ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/916819916819Ovarian Cancer Stem Cells: A New Target for Cancer TherapyQinglei Zhan0Chunmei Wang1Saiming Ngai2School of Life Sciences, The Chinese University of Hong Kong, New Territories, Hong KongSchool of Life Sciences, The Chinese University of Hong Kong, New Territories, Hong KongSchool of Life Sciences, The Chinese University of Hong Kong, New Territories, Hong KongOvarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are involved in drug resistance and cancer recurrence. Over the past decades, increasing studies have been done to identify CSCs from human ovarian cancer cells. The present paper will summarize different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance, and therapeutic approaches. Although there are still numerous challenges to translate basic research to clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent ovarian cancer and its recurrence.http://dx.doi.org/10.1155/2013/916819 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qinglei Zhan Chunmei Wang Saiming Ngai |
spellingShingle |
Qinglei Zhan Chunmei Wang Saiming Ngai Ovarian Cancer Stem Cells: A New Target for Cancer Therapy BioMed Research International |
author_facet |
Qinglei Zhan Chunmei Wang Saiming Ngai |
author_sort |
Qinglei Zhan |
title |
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy |
title_short |
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy |
title_full |
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy |
title_fullStr |
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy |
title_full_unstemmed |
Ovarian Cancer Stem Cells: A New Target for Cancer Therapy |
title_sort |
ovarian cancer stem cells: a new target for cancer therapy |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Ovarian cancer is a highly lethal disease among all gynecologic malignancies and is the fifth leading cause of cancer-related death in women. Although the standard combination of surgery and chemotherapy was initially effective in patients with ovarian cancer, disease relapse commonly occurred due to the generation of chemoresistance. It has been reported that cancer stem cells (CSCs) are involved in drug resistance and cancer recurrence. Over the past decades, increasing studies have been done to identify CSCs from human ovarian cancer cells. The present paper will summarize different investigations on ovarian CSCs, including isolation, mechanisms of chemoresistance, and therapeutic approaches. Although there are still numerous challenges to translate basic research to clinical applications, understanding the molecular details of CSCs is essential for developing effective strategies to prevent ovarian cancer and its recurrence. |
url |
http://dx.doi.org/10.1155/2013/916819 |
work_keys_str_mv |
AT qingleizhan ovariancancerstemcellsanewtargetforcancertherapy AT chunmeiwang ovariancancerstemcellsanewtargetforcancertherapy AT saimingngai ovariancancerstemcellsanewtargetforcancertherapy |
_version_ |
1725987468609585152 |