Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model
Objective: The present study investigated the effects of gallic acid (GA) administration on trimethyltin chloride (TMT) induced anxiety, depression, and hippocampal neurodegeneration in rats. Materials and Methods: In this experimental study, the rats received intraperitoneal (i.p.) injections o...
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doaj-06a8b509c38841dc875b0206695121f32020-11-25T03:32:10ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142016-02-01174659667Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication ModelMarzieh Moghadas0Mohammad Amin Edalatmanesh1Reza Robati2Department of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, IranDepartment of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, IranDepartment of Physiology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, IranObjective: The present study investigated the effects of gallic acid (GA) administration on trimethyltin chloride (TMT) induced anxiety, depression, and hippocampal neurodegeneration in rats. Materials and Methods: In this experimental study, the rats received intraperitoneal (i.p.) injections of TMT (8 mg/kg). The animals received either GA (50, 100 and 150 mg/kg) or saline as the vehicle for 14 consecutive days. We measured depression and anxiety levels of the rats by conducting the behavioral tail suspension (TST), elevatedplusmaze (EPM), and novelty suppressed feeding (NSF) tests. Histological analyses were then used to determine the cell densities of different hippocampal subdivisions. The data were analyzed with ANOVA and Tukey’s post hoc test. Results: GA administration ameliorated anxiety and depression in the behavioral tests. The cell densities in the CA1, CA2, CA3 and DG hippocampal subdivisionsfrom GA-treated rats were higher than saline treated rats. Conclusion: GA treatment against TMT-induced hippocampal degeneration altered cellular loss in the hippocampus and ameliorated the depression-anxiety state in rats.http://celljournal.org/web/journal/article/1209/downloadTrimethyltinGallic AcidHippocampusCell Density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marzieh Moghadas Mohammad Amin Edalatmanesh Reza Robati |
spellingShingle |
Marzieh Moghadas Mohammad Amin Edalatmanesh Reza Robati Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model Cell Journal Trimethyltin Gallic Acid Hippocampus Cell Density |
author_facet |
Marzieh Moghadas Mohammad Amin Edalatmanesh Reza Robati |
author_sort |
Marzieh Moghadas |
title |
Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model |
title_short |
Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model |
title_full |
Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model |
title_fullStr |
Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model |
title_full_unstemmed |
Histopathological Analysis from Gallic Acid Administration on Hippocampal Cell Density, Depression, and Anxiety Related Behaviors in A Trimethyltin Intoxication Model |
title_sort |
histopathological analysis from gallic acid administration on hippocampal cell density, depression, and anxiety related behaviors in a trimethyltin intoxication model |
publisher |
Royan Institute (ACECR), Tehran |
series |
Cell Journal |
issn |
2228-5806 2228-5814 |
publishDate |
2016-02-01 |
description |
Objective: The present study investigated the effects of gallic acid (GA) administration on
trimethyltin chloride (TMT) induced anxiety, depression, and hippocampal neurodegeneration
in rats.
Materials and Methods: In this experimental study, the rats received intraperitoneal (i.p.)
injections of TMT (8 mg/kg). The animals received either GA (50, 100 and 150 mg/kg) or
saline as the vehicle for 14 consecutive days. We measured depression and anxiety levels
of the rats by conducting the behavioral tail suspension (TST), elevatedplusmaze (EPM),
and novelty suppressed feeding (NSF) tests. Histological analyses were then used to determine
the cell densities of different hippocampal subdivisions. The data were analyzed
with ANOVA and Tukey’s post hoc test.
Results: GA administration ameliorated anxiety and depression in the behavioral tests.
The cell densities in the CA1, CA2, CA3 and DG hippocampal subdivisionsfrom GA-treated
rats were higher than saline treated rats.
Conclusion: GA treatment against TMT-induced hippocampal degeneration altered
cellular loss in the hippocampus and ameliorated the depression-anxiety state in rats. |
topic |
Trimethyltin Gallic Acid Hippocampus Cell Density |
url |
http://celljournal.org/web/journal/article/1209/download |
work_keys_str_mv |
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