Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow

Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow

Abstract Background Antigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with age, leading to an accumulation of highly differentiated T cells and a lo...

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Bibliographic Details
Main Authors: Erin Naismith, Luca Pangrazzi, Marco Grasse, Michael Keller, Carina Miggitsch, Birgit Weinberger, Klemens Trieb, Beatrix Grubeck-Loebenstein
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Immunity & Ageing
Subjects:
Bone marrow
Aging
Inflammation
Pro-inflammatory
Immunosenescence
Senescence
Online Access:http://link.springer.com/article/10.1186/s12979-019-0161-z

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