3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting Phenotype

3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting Phenotype

Tumor immune response is shaped by the tumor microenvironment (TME), which often evolves to be immunosuppressive, promoting disease progression and metastasis. An important example is melanoma tumors, which display high numbers of tumor-associated macrophages (TAMs) that are immunosuppressive but al...

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Bibliographic Details
Main Authors: Gabriela A. Pizzurro, Chang Liu, Kathryn Bridges, Amanda F. Alexander, Alice Huang, Janani P. Baskaran, Julie Ramseier, Marcus W. Bosenberg, Michael Mak, Kathryn Miller-Jensen
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
melanoma
tumor microenvironment
tumor-associated macrophages
fibroblasts
type I collagen
3D culture
Online Access:https://www.mdpi.com/2072-6694/13/18/4579

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