Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic appli...

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Main Authors:	Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04428-w

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spelling	doaj-06b7a3c5022e4c038a921dde8d876ca72021-05-11T09:57:39ZengNature Publishing GroupNature Communications2041-17232018-05-019111510.1038/s41467-018-04428-wRhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domainUlrike Scheib0Matthias Broser1Oana M. Constantin2Shang Yang3Shiqiang Gao4Shatanik Mukherjee5Katja Stehfest6Georg Nagel7Christine E. Gee8Peter Hegemann9Institute for Biology, Experimental Biophysics, Humboldt-Universität zu BerlinInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu BerlinInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-EppendorfDepartment of Biology, Institute for Molecular Plant Physiology and Biophysics, Biocenter, Julius-Maximilians-University of WürzburgDepartment of Biology, Institute for Molecular Plant Physiology and Biophysics, Biocenter, Julius-Maximilians-University of WürzburgInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu BerlinInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu BerlinDepartment of Biology, Institute for Molecular Plant Physiology and Biophysics, Biocenter, Julius-Maximilians-University of WürzburgInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-EppendorfInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu BerlinCyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic applications.https://doi.org/10.1038/s41467-018-04428-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann
spellingShingle	Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain Nature Communications
author_facet	Ulrike Scheib Matthias Broser Oana M. Constantin Shang Yang Shiqiang Gao Shatanik Mukherjee Katja Stehfest Georg Nagel Christine E. Gee Peter Hegemann
author_sort	Ulrike Scheib
title	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_short	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_full	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_fullStr	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_full_unstemmed	Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
title_sort	rhodopsin-cyclases for photocontrol of cgmp/camp and 2.3 å structure of the adenylyl cyclase domain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the usability of these cyclases for optogenetic applications.
url	https://doi.org/10.1038/s41467-018-04428-w
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Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

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