Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment

The environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate...

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Main Authors:	Olivier Baud, Nadia Berkane
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-03-01
Series:	Frontiers in Endocrinology
Subjects:	intra-uterine growth restriction brain development glucocorticoids neurosteroids insulin growth factor thyroid hormones
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2019.00179/full

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spelling	doaj-06b9f18b8ba941838ca616804245300e2020-11-24T21:54:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-03-011010.3389/fendo.2019.00179439033Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future NeurodevelopmentOlivier Baud0Olivier Baud1Nadia Berkane2Division of Neonatology and Pediatric Intensive Care, Department of Women-Children-Teenagers, University Hospitals Geneva, Geneva, SwitzerlandInserm U1141, Sorbonne, Paris Diderot University, Paris, FranceDivision of Obstetrics and Gynecology, Department of Women-Children-Teenagers, University Hospitals Geneva, Geneva, SwitzerlandThe environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate the growth of the fetus and its metabolism during pregnancy by controlling the supply of nutrients crossing the placenta. In addition to fetal synthesis, hormones regulating fetal growth are also expressed and regulated in the placenta, and they play a key role in the vulnerability of the developing brain and its maturation. This review summarizes the current understanding and evidence regarding the involvement of hormonal dysregulation associated with intra-uterine growth restriction and its consequences on brain development.https://www.frontiersin.org/article/10.3389/fendo.2019.00179/fullintra-uterine growth restrictionbrain developmentglucocorticoidsneurosteroidsinsulin growth factorthyroid hormones
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Olivier Baud Olivier Baud Nadia Berkane
spellingShingle	Olivier Baud Olivier Baud Nadia Berkane Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment Frontiers in Endocrinology intra-uterine growth restriction brain development glucocorticoids neurosteroids insulin growth factor thyroid hormones
author_facet	Olivier Baud Olivier Baud Nadia Berkane
author_sort	Olivier Baud
title	Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment
title_short	Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment
title_full	Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment
title_fullStr	Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment
title_full_unstemmed	Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment
title_sort	hormonal changes associated with intra-uterine growth restriction: impact on the developing brain and future neurodevelopment
publisher	Frontiers Media S.A.
series	Frontiers in Endocrinology
issn	1664-2392
publishDate	2019-03-01
description	The environment in which a fetus develops is not only important for its growth and maturation but also for its long-term postnatal health and neurodevelopment. Several hormones including glucocorticosteroids, estrogens and progesterone, insulin growth factor and thyroid hormones, carefully regulate the growth of the fetus and its metabolism during pregnancy by controlling the supply of nutrients crossing the placenta. In addition to fetal synthesis, hormones regulating fetal growth are also expressed and regulated in the placenta, and they play a key role in the vulnerability of the developing brain and its maturation. This review summarizes the current understanding and evidence regarding the involvement of hormonal dysregulation associated with intra-uterine growth restriction and its consequences on brain development.
topic	intra-uterine growth restriction brain development glucocorticoids neurosteroids insulin growth factor thyroid hormones
url	https://www.frontiersin.org/article/10.3389/fendo.2019.00179/full
work_keys_str_mv	AT olivierbaud hormonalchangesassociatedwithintrauterinegrowthrestrictionimpactonthedevelopingbrainandfutureneurodevelopment AT olivierbaud hormonalchangesassociatedwithintrauterinegrowthrestrictionimpactonthedevelopingbrainandfutureneurodevelopment AT nadiaberkane hormonalchangesassociatedwithintrauterinegrowthrestrictionimpactonthedevelopingbrainandfutureneurodevelopment
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Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment

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