Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.

While the relationship between total cholesterol (TC) and cardiovascular disease (CVD) progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important...

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Main Authors: Giovanni Zuliani, Stefano Volpato, Marco Dugo, Giovanni B Vigna, Mario Luca Morieri, Marcello Maggio, Antonio Cherubini, Stefania Bandinelli, Jack M Guralnik, Luigi Ferrucci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5619755?pdf=render
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spelling doaj-06bb887123bd46e3b3d8ee34f74fd4002020-11-25T00:24:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018530710.1371/journal.pone.0185307Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.Giovanni ZulianiStefano VolpatoMarco DugoGiovanni B VignaMario Luca MorieriMarcello MaggioAntonio CherubiniStefania BandinelliJack M GuralnikLuigi FerrucciWhile the relationship between total cholesterol (TC) and cardiovascular disease (CVD) progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C) to mortality risk has not been previously investigated. Our study aimed to investigate the relationship between baseline LDL-C and HDL-C, both separately and combined, and 9-years mortality in a sample of community dwelling older individuals from the InCHIANTI study.1044 individuals over 64 years were included. CVD and cancer mortality were defined by ICD-9 codes 390-459 and 140-239, respectively. LDL-C <130 mg/dL (3.36 mmol/L) was defined as "optimal/near optimal". Low HDL-C was defined as <40/50 mg/dL (1.03/1.29 mmol/L) in males/females, respectively. Nine-years mortality risk was calculated by multivariate Cox proportional hazards model. We found that, compared to subjects with high LDL-C and normal HDL-C (reference group), total mortality was significantly increased in subjects with optimal/near optimal LDL-C and low HDL-C (H.R.:1.58; 95%CI:1.11-2.25). As regards the specific cause of death, CVD mortality was not affected by LDL-C/HDL-C levels, while cancer mortality was significantly increased in all subjects with optimal/near optimal LDL-C (with normal HDL-C: H.R.: 2.49; with low HDL-C: H.R.: 4.52). Results were unchanged after exclusion of the first three years of follow-up, and of subjects with low TC (<160 g/dL-4.13 mmol/L).Our findings suggest that, in community dwelling older individuals, the combined presence of optimal/near optimal LDL-C and low HDL-C represents a marker of increased future mortality.http://europepmc.org/articles/PMC5619755?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Giovanni Zuliani
Stefano Volpato
Marco Dugo
Giovanni B Vigna
Mario Luca Morieri
Marcello Maggio
Antonio Cherubini
Stefania Bandinelli
Jack M Guralnik
Luigi Ferrucci
spellingShingle Giovanni Zuliani
Stefano Volpato
Marco Dugo
Giovanni B Vigna
Mario Luca Morieri
Marcello Maggio
Antonio Cherubini
Stefania Bandinelli
Jack M Guralnik
Luigi Ferrucci
Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
PLoS ONE
author_facet Giovanni Zuliani
Stefano Volpato
Marco Dugo
Giovanni B Vigna
Mario Luca Morieri
Marcello Maggio
Antonio Cherubini
Stefania Bandinelli
Jack M Guralnik
Luigi Ferrucci
author_sort Giovanni Zuliani
title Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
title_short Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
title_full Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
title_fullStr Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
title_full_unstemmed Combining LDL-C and HDL-C to predict survival in late life: The InChianti study.
title_sort combining ldl-c and hdl-c to predict survival in late life: the inchianti study.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description While the relationship between total cholesterol (TC) and cardiovascular disease (CVD) progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C) to mortality risk has not been previously investigated. Our study aimed to investigate the relationship between baseline LDL-C and HDL-C, both separately and combined, and 9-years mortality in a sample of community dwelling older individuals from the InCHIANTI study.1044 individuals over 64 years were included. CVD and cancer mortality were defined by ICD-9 codes 390-459 and 140-239, respectively. LDL-C <130 mg/dL (3.36 mmol/L) was defined as "optimal/near optimal". Low HDL-C was defined as <40/50 mg/dL (1.03/1.29 mmol/L) in males/females, respectively. Nine-years mortality risk was calculated by multivariate Cox proportional hazards model. We found that, compared to subjects with high LDL-C and normal HDL-C (reference group), total mortality was significantly increased in subjects with optimal/near optimal LDL-C and low HDL-C (H.R.:1.58; 95%CI:1.11-2.25). As regards the specific cause of death, CVD mortality was not affected by LDL-C/HDL-C levels, while cancer mortality was significantly increased in all subjects with optimal/near optimal LDL-C (with normal HDL-C: H.R.: 2.49; with low HDL-C: H.R.: 4.52). Results were unchanged after exclusion of the first three years of follow-up, and of subjects with low TC (<160 g/dL-4.13 mmol/L).Our findings suggest that, in community dwelling older individuals, the combined presence of optimal/near optimal LDL-C and low HDL-C represents a marker of increased future mortality.
url http://europepmc.org/articles/PMC5619755?pdf=render
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