Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated...

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Main Authors:	Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02541-w

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spelling	doaj-06c00b6672ba4168b243c12ea9e270072021-05-11T10:27:21ZengNature Publishing GroupNature Communications2041-17232018-01-019111210.1038/s41467-017-02541-wDirect cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivoMasayuki Furuya0Junichi Kikuta1Sayumi Fujimori2Shigeto Seno3Hiroki Maeda4Mai Shirazaki5Maki Uenaka6Hiroki Mizuno7Yoriko Iwamoto8Akito Morimoto9Kunihiko Hashimoto10Takeshi Ito11Yukihiro Isogai12Masafumi Kashii13Takashi Kaito14Shinsuke Ohba15Ung-il Chung16Alexander C. Lichtler17Kazuya Kikuchi18Hideo Matsuda19Hideki Yoshikawa20Masaru Ishii21Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Cellular Dynamics, WPI-Immunology Frontier Research Center, Osaka UniversityDepartment of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka UniversityDepartment of Material and Life Sciences, Graduate School of Engineering, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityLaboratory for Pharmacology, Pharmaceutical Research Center, Asahi Kasei Pharma CorporationMedical Affairs Department, Pharmaceutical Business Administration Division, Asahi Kasei Pharma CorporationDepartment of Orthopaedics, Graduate School of Medicine, Osaka UniversityDepartment of Orthopaedics, Graduate School of Medicine, Osaka UniversityDivision of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of TokyoDivision of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of TokyoDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health CenterDepartment of Material and Life Sciences, Graduate School of Engineering, Osaka UniversityDepartment of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka UniversityDepartment of Orthopaedics, Graduate School of Medicine, Osaka UniversityDepartment of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka UniversityCommunication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.https://doi.org/10.1038/s41467-017-02541-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Masayuki Furuya Junichi Kikuta Sayumi Fujimori Shigeto Seno Hiroki Maeda Mai Shirazaki Maki Uenaka Hiroki Mizuno Yoriko Iwamoto Akito Morimoto Kunihiko Hashimoto Takeshi Ito Yukihiro Isogai Masafumi Kashii Takashi Kaito Shinsuke Ohba Ung-il Chung Alexander C. Lichtler Kazuya Kikuchi Hideo Matsuda Hideki Yoshikawa Masaru Ishii
spellingShingle	Masayuki Furuya Junichi Kikuta Sayumi Fujimori Shigeto Seno Hiroki Maeda Mai Shirazaki Maki Uenaka Hiroki Mizuno Yoriko Iwamoto Akito Morimoto Kunihiko Hashimoto Takeshi Ito Yukihiro Isogai Masafumi Kashii Takashi Kaito Shinsuke Ohba Ung-il Chung Alexander C. Lichtler Kazuya Kikuchi Hideo Matsuda Hideki Yoshikawa Masaru Ishii Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo Nature Communications
author_facet	Masayuki Furuya Junichi Kikuta Sayumi Fujimori Shigeto Seno Hiroki Maeda Mai Shirazaki Maki Uenaka Hiroki Mizuno Yoriko Iwamoto Akito Morimoto Kunihiko Hashimoto Takeshi Ito Yukihiro Isogai Masafumi Kashii Takashi Kaito Shinsuke Ohba Ung-il Chung Alexander C. Lichtler Kazuya Kikuchi Hideo Matsuda Hideki Yoshikawa Masaru Ishii
author_sort	Masayuki Furuya
title	Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_short	Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_full	Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_fullStr	Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_full_unstemmed	Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
title_sort	direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.
url	https://doi.org/10.1038/s41467-017-02541-w
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Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

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