The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clin...

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Main Authors: Malgorzata Banys, Natalia Krawczyk, Tanja Fehm
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Cancers
Subjects:
breast cancer
bone marrow
disseminated tumor cell
circulating tumor cell
tumor cell dissemination
Online Access:http://www.mdpi.com/2072-6694/6/1/143
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spelling doaj-06d3f6885a8b42b0b0a0b292504ca4ea2020-11-24T23:10:37ZengMDPI AGCancers2072-66942014-01-016114315210.3390/cancers6010143cancers6010143The Role and Clinical Relevance of Disseminated Tumor Cells in Breast CancerMalgorzata Banys0Natalia Krawczyk1Tanja Fehm2Department of Obstetrics and Gynecology, University of Duesseldorf, Duesseldorf D-40225, GermanyDepartment of Obstetrics and Gynecology, University of Duesseldorf, Duesseldorf D-40225, GermanyDepartment of Obstetrics and Gynecology, University of Duesseldorf, Duesseldorf D-40225, GermanyTumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.http://www.mdpi.com/2072-6694/6/1/143breast cancerbone marrowdisseminated tumor cellcirculating tumor celltumor cell dissemination
collection DOAJ
language English
format Article
sources DOAJ
author Malgorzata Banys
Natalia Krawczyk
Tanja Fehm
spellingShingle Malgorzata Banys
Natalia Krawczyk
Tanja Fehm
The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
Cancers
breast cancer
bone marrow
disseminated tumor cell
circulating tumor cell
tumor cell dissemination
author_facet Malgorzata Banys
Natalia Krawczyk
Tanja Fehm
author_sort Malgorzata Banys
title The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_short The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_full The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_fullStr The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_full_unstemmed The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer
title_sort role and clinical relevance of disseminated tumor cells in breast cancer
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2014-01-01
description Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.
topic breast cancer
bone marrow
disseminated tumor cell
circulating tumor cell
tumor cell dissemination
url http://www.mdpi.com/2072-6694/6/1/143
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