Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4

Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4

The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell functions. Here we include data on human neutrophi...

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Main Authors: André Holdfeldt, Malene Winther, Michael Gabl, Claes Dahlgren, Huamei Forsman
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340916303535
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spelling doaj-06d48cf33d7047f3a4b47128e2885a982020-11-25T01:44:32ZengElsevierData in Brief2352-34092016-09-018411414Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4André Holdfeldt0Malene Winther1Michael Gabl2Claes Dahlgren3Huamei Forsman4Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, SwedenDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, SwedenDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, SwedenDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, SwedenCorresponding author: Tel.: +46 31 3424972; Mobile: +46 070 8701899.; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, SwedenThe data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell functions. Here we include data on human neutrophil function induced by pepducins derived from β2AR (ICL3-8) and CXCR4 (ATI-2341), respectively. ICL3-8 exerts neither direct activating effect on the NADPH-oxidase as measured by superoxide release nor inhibitory effect on FPR signaling. ATI-2341 dose-dependently triggers neutrophil activation and these cells were subsequently desensitized in their response to FPR2 specific agonists F2Pal10 and WKYMVM. Moreover, the ATI-2341 response is inhibited by PBP10 and the peptidomimetic Pam-(Lys-betaNSpe)6-NH2 (both are FPR2 specific inhibitors), but not to the FPR1 specific inhibitor cyclosporine H.http://www.sciencedirect.com/science/article/pii/S2352340916303535
collection DOAJ
language English
format Article
sources DOAJ
author André Holdfeldt
Malene Winther
Michael Gabl
Claes Dahlgren
Huamei Forsman
spellingShingle André Holdfeldt
Malene Winther
Michael Gabl
Claes Dahlgren
Huamei Forsman
Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
Data in Brief
author_facet André Holdfeldt
Malene Winther
Michael Gabl
Claes Dahlgren
Huamei Forsman
author_sort André Holdfeldt
title Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
title_short Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
title_full Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
title_fullStr Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
title_full_unstemmed Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4
title_sort data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2ar and cxcr4
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2016-09-01
description The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell functions. Here we include data on human neutrophil function induced by pepducins derived from β2AR (ICL3-8) and CXCR4 (ATI-2341), respectively. ICL3-8 exerts neither direct activating effect on the NADPH-oxidase as measured by superoxide release nor inhibitory effect on FPR signaling. ATI-2341 dose-dependently triggers neutrophil activation and these cells were subsequently desensitized in their response to FPR2 specific agonists F2Pal10 and WKYMVM. Moreover, the ATI-2341 response is inhibited by PBP10 and the peptidomimetic Pam-(Lys-betaNSpe)6-NH2 (both are FPR2 specific inhibitors), but not to the FPR1 specific inhibitor cyclosporine H.
url http://www.sciencedirect.com/science/article/pii/S2352340916303535
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