Insulin-Producing Cell Transplantation Platform for Veterinary Practice
Diabetes mellitus (DM) remains a global concern in both human and veterinary medicine. Type I DM requires prolonged and consistent exogenous insulin administration to address hyperglycemia, which can increase the risk of diabetes complications such as retinopathy, nephropathy, neuropathy, and heart...
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2020-02-01
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doaj-06d5a7cd6ee2466390e023b35578ac0a2020-11-25T01:42:25ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692020-02-01710.3389/fvets.2020.00004503887Insulin-Producing Cell Transplantation Platform for Veterinary PracticeSuryo Kuncorojakti0Suryo Kuncorojakti1Sayamon Srisuwatanasagul2Krishaporn Kradangnga3Chenphop Sawangmake4Chenphop Sawangmake5Chenphop Sawangmake6Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Veterinary Pharmacology and Stem Cell Research Laboratory, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandDepartment of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Anatomy, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandDepartment of Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandVeterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Veterinary Pharmacology and Stem Cell Research Laboratory, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandVeterinary Clinical Stem Cell and Bioengineering Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandDepartment of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, ThailandDiabetes mellitus (DM) remains a global concern in both human and veterinary medicine. Type I DM requires prolonged and consistent exogenous insulin administration to address hyperglycemia, which can increase the risk of diabetes complications such as retinopathy, nephropathy, neuropathy, and heart disorders. Cell-based therapies have been successful in human medicine using the Edmonton protocol. These therapies help maintain the production of endogenous insulin and stabilize blood glucose levels and may possibly be adapted to veterinary clinical practice. The limited number of cadaveric pancreas donors and the long-term use of immunosuppressive agents are the main obstacles for this protocol. Over the past decade, the development of potential therapies for DM has mainly focused on the generation of effective insulin-producing cells (IPCs) from various sources of stem cells that can be transplanted into the body. Another successful application of stem cells in type I DM therapies is transplanting generated IPCs. Encapsulation can be an alternative strategy to protect IPCs from rejection by the body due to their immunoisolation properties. This review summarizes current concepts of IPCs and encapsulation technology for veterinary clinical application and proposes a potential stem-cell-based platform for veterinary diabetic regenerative therapy.https://www.frontiersin.org/article/10.3389/fvets.2020.00004/fulldiabetes mellitusveterinary stem cell-based therapyregenerative medicineencapsulationtissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suryo Kuncorojakti Suryo Kuncorojakti Sayamon Srisuwatanasagul Krishaporn Kradangnga Chenphop Sawangmake Chenphop Sawangmake Chenphop Sawangmake |
spellingShingle |
Suryo Kuncorojakti Suryo Kuncorojakti Sayamon Srisuwatanasagul Krishaporn Kradangnga Chenphop Sawangmake Chenphop Sawangmake Chenphop Sawangmake Insulin-Producing Cell Transplantation Platform for Veterinary Practice Frontiers in Veterinary Science diabetes mellitus veterinary stem cell-based therapy regenerative medicine encapsulation tissue engineering |
author_facet |
Suryo Kuncorojakti Suryo Kuncorojakti Sayamon Srisuwatanasagul Krishaporn Kradangnga Chenphop Sawangmake Chenphop Sawangmake Chenphop Sawangmake |
author_sort |
Suryo Kuncorojakti |
title |
Insulin-Producing Cell Transplantation Platform for Veterinary Practice |
title_short |
Insulin-Producing Cell Transplantation Platform for Veterinary Practice |
title_full |
Insulin-Producing Cell Transplantation Platform for Veterinary Practice |
title_fullStr |
Insulin-Producing Cell Transplantation Platform for Veterinary Practice |
title_full_unstemmed |
Insulin-Producing Cell Transplantation Platform for Veterinary Practice |
title_sort |
insulin-producing cell transplantation platform for veterinary practice |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Veterinary Science |
issn |
2297-1769 |
publishDate |
2020-02-01 |
description |
Diabetes mellitus (DM) remains a global concern in both human and veterinary medicine. Type I DM requires prolonged and consistent exogenous insulin administration to address hyperglycemia, which can increase the risk of diabetes complications such as retinopathy, nephropathy, neuropathy, and heart disorders. Cell-based therapies have been successful in human medicine using the Edmonton protocol. These therapies help maintain the production of endogenous insulin and stabilize blood glucose levels and may possibly be adapted to veterinary clinical practice. The limited number of cadaveric pancreas donors and the long-term use of immunosuppressive agents are the main obstacles for this protocol. Over the past decade, the development of potential therapies for DM has mainly focused on the generation of effective insulin-producing cells (IPCs) from various sources of stem cells that can be transplanted into the body. Another successful application of stem cells in type I DM therapies is transplanting generated IPCs. Encapsulation can be an alternative strategy to protect IPCs from rejection by the body due to their immunoisolation properties. This review summarizes current concepts of IPCs and encapsulation technology for veterinary clinical application and proposes a potential stem-cell-based platform for veterinary diabetic regenerative therapy. |
topic |
diabetes mellitus veterinary stem cell-based therapy regenerative medicine encapsulation tissue engineering |
url |
https://www.frontiersin.org/article/10.3389/fvets.2020.00004/full |
work_keys_str_mv |
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