Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease
Alzheimer's disease (AD)—the most common type of dementia among the elderly—represents one of the most challenging and urgent medical mysteries affecting our aging population. Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelmi...
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Series: | International Journal of Alzheimer's Disease |
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doaj-06d7b6a116764c0d8acb70acdb9e481b2020-11-25T00:55:25ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-02522011-01-01201110.4061/2011/974361974361Function and Comorbidities of Apolipoprotein E in Alzheimer's DiseaseValérie Leduc0Dorothée Domenger1Louis De Beaumont2Daphnée Lalonde3Stéphanie Bélanger-Jasmin4Judes Poirier5Department of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaDepartment of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaDepartment of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaDepartment of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaDepartment of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaDepartment of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E-3207.1, 6875 Lasalle Boulevard, Verdun, QC, H4H 1R3, CanadaAlzheimer's disease (AD)—the most common type of dementia among the elderly—represents one of the most challenging and urgent medical mysteries affecting our aging population. Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelming majority of AD cases, dubbed sporadic AD, do not display this Mendelian inheritance pattern. Apolipoprotein E (APOE), the main lipid carrier protein in the central nervous system, is the only gene that has been robustly and consistently associated with AD risk. The purpose of the current paper is thus to highlight the pleiotropic roles and the structure-function relationship of APOE to stimulate both the functional characterization and the identification of novel lipid homeostasis-related molecular targets involved in AD.http://dx.doi.org/10.4061/2011/974361 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valérie Leduc Dorothée Domenger Louis De Beaumont Daphnée Lalonde Stéphanie Bélanger-Jasmin Judes Poirier |
spellingShingle |
Valérie Leduc Dorothée Domenger Louis De Beaumont Daphnée Lalonde Stéphanie Bélanger-Jasmin Judes Poirier Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease International Journal of Alzheimer's Disease |
author_facet |
Valérie Leduc Dorothée Domenger Louis De Beaumont Daphnée Lalonde Stéphanie Bélanger-Jasmin Judes Poirier |
author_sort |
Valérie Leduc |
title |
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease |
title_short |
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease |
title_full |
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease |
title_fullStr |
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease |
title_full_unstemmed |
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease |
title_sort |
function and comorbidities of apolipoprotein e in alzheimer's disease |
publisher |
Hindawi Limited |
series |
International Journal of Alzheimer's Disease |
issn |
2090-0252 |
publishDate |
2011-01-01 |
description |
Alzheimer's disease (AD)—the most common type of dementia among the elderly—represents one of the most challenging and urgent medical mysteries affecting our aging population. Although dominant inherited mutation in genes involved in the amyloid metabolism can elicit familial AD, the overwhelming majority of AD cases, dubbed sporadic AD, do not display this Mendelian inheritance pattern. Apolipoprotein E (APOE), the main lipid carrier protein in the central nervous system, is the only gene that has been robustly and consistently associated with AD risk. The purpose of the current paper is thus to highlight the pleiotropic roles and the structure-function relationship of APOE to stimulate both the functional characterization and the identification of novel lipid homeostasis-related molecular targets involved in AD. |
url |
http://dx.doi.org/10.4061/2011/974361 |
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