The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues

The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues

Pelvic radiation for cancer therapy can damage a variety of normal tissues. In this study, we demonstrate that radiation causes acute changes to pelvic fibroblasts such as the transformation to myofibroblasts and the induction of senescence, which persist months after radiation. The addition of the...

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Bibliographic Details
Main Authors: Shashank Shrishrimal, Elizabeth A. Kosmacek, Arpita Chatterjee, McDonald J. Tyson, Rebecca E. Oberley-Deegan
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Antioxidants
Subjects:
MnTE-2-PyP
fibrosis
radiation
fibroblast
T cells
adipose
skin
bladder
NQO1
COL3A1
Online Access:https://www.mdpi.com/2076-3921/6/4/87

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