Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miR...

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Main Authors: Valentina Iadevaia, André P. Gerber
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Biomolecules
Subjects:
gene expression
post-transcriptional control
RNA-binding protein
microRNA
ribonucleoprotein complex
combinatorial control
Online Access:http://www.mdpi.com/2218-273X/5/4/2207
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spelling doaj-06ee99fcf685447392dcef27095952d42020-11-25T00:55:12ZengMDPI AGBiomolecules2218-273X2015-09-01542207222210.3390/biom5042207biom5042207Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAsValentina Iadevaia0André P. Gerber1Department of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UKDepartment of Microbial & Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UKPost-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.http://www.mdpi.com/2218-273X/5/4/2207gene expressionpost-transcriptional controlRNA-binding proteinmicroRNAribonucleoprotein complexcombinatorial control
collection DOAJ
language English
format Article
sources DOAJ
author Valentina Iadevaia
André P. Gerber
spellingShingle Valentina Iadevaia
André P. Gerber
Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
Biomolecules
gene expression
post-transcriptional control
RNA-binding protein
microRNA
ribonucleoprotein complex
combinatorial control
author_facet Valentina Iadevaia
André P. Gerber
author_sort Valentina Iadevaia
title Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
title_short Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
title_full Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
title_fullStr Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
title_full_unstemmed Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs
title_sort combinatorial control of mrna fates by rna-binding proteins and non-coding rnas
publisher MDPI AG
series Biomolecules
issn 2218-273X
publishDate 2015-09-01
description Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.
topic gene expression
post-transcriptional control
RNA-binding protein
microRNA
ribonucleoprotein complex
combinatorial control
url http://www.mdpi.com/2218-273X/5/4/2207
work_keys_str_mv AT valentinaiadevaia combinatorialcontrolofmrnafatesbyrnabindingproteinsandnoncodingrnas
AT andrepgerber combinatorialcontrolofmrnafatesbyrnabindingproteinsandnoncodingrnas
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