Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.
This study identifies metabolic and protein phenotypic alterations in gastrocnemius, tibialis anterior and diaphragm muscles of Col6a1(-/-) mice, a model of human collagen VI myopathies. All three muscles of Col6a1(-/-) mice show some common changes in proteins involved in metabolism, resulting in d...
Main Authors: | Sara De Palma, Roberta Leone, Paolo Grumati, Michele Vasso, Roman Polishchuk, Daniele Capitanio, Paola Braghetta, Paolo Bernardi, Paolo Bonaldo, Cecilia Gelfi |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3577731?pdf=render |
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