Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease
Quorum sensing in prokaryotic biology refers to the ability of a bacterium to sense information from other cells in the population when they reach a critical concentration (i.e. a Quorum) and communicate with them. The "language" used for this intercellular communication is based on small,...
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doaj-06f2e51ddc2d464bbc3d41b1192690072020-11-25T02:52:37ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262011-01-0130100401110.4103/0974-2727.78553Quorum sensing and Bacterial Pathogenicity: From Molecules to DiseaseAntariksh Deep0Uma Chaudhary1Varsha Gupta2Department of Microbiology, Pt. B.D. Sharma, PGIMS, Rohtak - 124 001, IndiaDepartment of Microbiology, Pt. B.D. Sharma, PGIMS, Rohtak - 124 001, IndiaDepartment of GMCH, Sector-32, Chandigarh, IndiaQuorum sensing in prokaryotic biology refers to the ability of a bacterium to sense information from other cells in the population when they reach a critical concentration (i.e. a Quorum) and communicate with them. The "language" used for this intercellular communication is based on small, self-generated signal molecules called as autoinducers. Quorum sensing is thought to afford pathogenic bacteria a mechanism to minimize host immune responses by delaying the production of tissue-damaging virulence factors until sufficient bacteria have amassed and are prepared to overwhelm host defense mechanisms and establish infection. Quorum sensing systems are studied in a large number of gram-negative bacterial species belonging to α, β, and γ subclasses of proteobacteria. Among the pathogenic bacteria, Pseudomonas aeruginosa is perhaps the best understood in terms of the virulence factors regulated and the role the Quorum sensing plays in pathogenicity. Presently, Quorum sensing is considered as a potential novel target for antimicrobial therapy to control multi/all drug-resistant infections. This paper reviews Quorum sensing in gram positive and gram negative bacteria and its role in biofilm formation.http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.78553autoinduceracyl homoserine lactonebiofilm quorum sensing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antariksh Deep Uma Chaudhary Varsha Gupta |
spellingShingle |
Antariksh Deep Uma Chaudhary Varsha Gupta Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease Journal of Laboratory Physicians autoinducer acyl homoserine lactone biofilm quorum sensing |
author_facet |
Antariksh Deep Uma Chaudhary Varsha Gupta |
author_sort |
Antariksh Deep |
title |
Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease |
title_short |
Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease |
title_full |
Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease |
title_fullStr |
Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease |
title_full_unstemmed |
Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease |
title_sort |
quorum sensing and bacterial pathogenicity: from molecules to disease |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Journal of Laboratory Physicians |
issn |
0974-2727 0974-7826 |
publishDate |
2011-01-01 |
description |
Quorum sensing in prokaryotic biology refers to the ability of a bacterium to sense information from other cells in the population when they reach a critical concentration (i.e. a Quorum) and communicate with them. The "language" used for this intercellular communication is based on small, self-generated signal molecules called as autoinducers. Quorum sensing is thought to afford pathogenic bacteria a mechanism to minimize host immune responses by delaying the production of tissue-damaging virulence factors until sufficient bacteria have amassed and are prepared to overwhelm host defense mechanisms and establish infection. Quorum sensing systems are studied in a large number of gram-negative bacterial species belonging to α, β, and γ subclasses of proteobacteria. Among the pathogenic bacteria, Pseudomonas aeruginosa is perhaps the best understood in terms of the virulence factors regulated and the role the Quorum sensing plays in pathogenicity. Presently, Quorum sensing is considered as a potential novel target for antimicrobial therapy to control multi/all drug-resistant infections. This paper reviews Quorum sensing in gram positive and gram negative bacteria and its role in biofilm formation. |
topic |
autoinducer acyl homoserine lactone biofilm quorum sensing |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.78553 |
work_keys_str_mv |
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