Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls
Abstract Background Compound strain imaging is a novel method to noninvasively evaluate arterial wall deformation which has recently shown to enable differentiation between fibrous and (fibro-)atheromatous plaques in patients with severe stenosis. We tested the hypothesis that compound strain imagin...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-05-01
|
Series: | Cardiovascular Ultrasound |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12947-017-0104-9 |
id |
doaj-0700e114755b4cddb99722a04919213b |
---|---|
record_format |
Article |
spelling |
doaj-0700e114755b4cddb99722a04919213b2020-11-24T23:54:00ZengBMCCardiovascular Ultrasound1476-71202017-05-011511810.1186/s12947-017-0104-9Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controlsMartijn F.H. Maessen0Thijs M.H. Eijsvogels1Ayla Grotens2Maria T.E. Hopman3Dick H.J. Thijssen4Hendrik H.G. Hansen5Department of Physiology, Radboud university medical centerDepartment of Physiology, Radboud university medical centerDepartment of Physiology, Radboud university medical centerDepartment of Physiology, Radboud university medical centerDepartment of Physiology, Radboud university medical centerDepartment of Radiology and Nuclear Medicine, Radboud university medical center, Medical UltraSound Imaging Center (MUSIC)Abstract Background Compound strain imaging is a novel method to noninvasively evaluate arterial wall deformation which has recently shown to enable differentiation between fibrous and (fibro-)atheromatous plaques in patients with severe stenosis. We tested the hypothesis that compound strain imaging is feasible in non-stenotic arteries and provides incremental discriminative power to traditional measures of vascular health (i.e., distensibility coefficient (DC), central pulse wave velocity [cPWV], and intima-media thickness [IMT]) for differentiating between participants with and without a history of cardiovascular diseases (CVD). Methods Seventy two participants (60 ± 7 years) with non-stenotic arteries (IMT < 1.1 mm) were categorized in healthy participants (CON, n = 36) and CVD patients (n = 36) based on CVD history. Participants underwent standardised ultrasound-based assessment (DC, cPWV, and IMT) and compound strain imaging (radial [RS] and circumferential [CS] strain) in left common carotid artery. Area under receiver operating characteristics (AROC)-curve was used to determine the discriminatory power between CVD and CON of the various measures. Results CON had a significantly (P < 0.05) smaller carotid IMT (0.68 [0.58 to 0.76] mm) than CVD patients (0.76 [0.68 to 0.80] mm). DC, cPWV, RS, and CS did not significantly differ between groups (P > 0.05). A higher CS or RS was associated with a higher DC (CS: r = −0.32;p < 0.05 and RS: r = 0.24;p < 0.05) and lower cPWV (CS: r = 0.24;p < 0.05 and RS: r = −0.25;p < 0.05). IMT could identify CVD (AROC: 0.66, 95%-CI: 0.53 to 0.79), whilst the other measurements, alone or in combination, did not significantly increase the discriminatory power compared to IMT. Conclusions In non-stenotic arteries, compound strain imaging is feasible, but does not seem to provide incremental discriminative power to traditional measures of vascular health for differentiation between individuals with and without a history of CVD.http://link.springer.com/article/10.1186/s12947-017-0104-9Strain imagingMyocardial infarctionUltrasound imagingCardiovascular assessmentIntima media thickness |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martijn F.H. Maessen Thijs M.H. Eijsvogels Ayla Grotens Maria T.E. Hopman Dick H.J. Thijssen Hendrik H.G. Hansen |
spellingShingle |
Martijn F.H. Maessen Thijs M.H. Eijsvogels Ayla Grotens Maria T.E. Hopman Dick H.J. Thijssen Hendrik H.G. Hansen Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls Cardiovascular Ultrasound Strain imaging Myocardial infarction Ultrasound imaging Cardiovascular assessment Intima media thickness |
author_facet |
Martijn F.H. Maessen Thijs M.H. Eijsvogels Ayla Grotens Maria T.E. Hopman Dick H.J. Thijssen Hendrik H.G. Hansen |
author_sort |
Martijn F.H. Maessen |
title |
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
title_short |
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
title_full |
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
title_fullStr |
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
title_full_unstemmed |
Feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
title_sort |
feasibility and relevance of compound strain imaging in non-stenotic arteries: comparison between individuals with cardiovascular diseases and healthy controls |
publisher |
BMC |
series |
Cardiovascular Ultrasound |
issn |
1476-7120 |
publishDate |
2017-05-01 |
description |
Abstract Background Compound strain imaging is a novel method to noninvasively evaluate arterial wall deformation which has recently shown to enable differentiation between fibrous and (fibro-)atheromatous plaques in patients with severe stenosis. We tested the hypothesis that compound strain imaging is feasible in non-stenotic arteries and provides incremental discriminative power to traditional measures of vascular health (i.e., distensibility coefficient (DC), central pulse wave velocity [cPWV], and intima-media thickness [IMT]) for differentiating between participants with and without a history of cardiovascular diseases (CVD). Methods Seventy two participants (60 ± 7 years) with non-stenotic arteries (IMT < 1.1 mm) were categorized in healthy participants (CON, n = 36) and CVD patients (n = 36) based on CVD history. Participants underwent standardised ultrasound-based assessment (DC, cPWV, and IMT) and compound strain imaging (radial [RS] and circumferential [CS] strain) in left common carotid artery. Area under receiver operating characteristics (AROC)-curve was used to determine the discriminatory power between CVD and CON of the various measures. Results CON had a significantly (P < 0.05) smaller carotid IMT (0.68 [0.58 to 0.76] mm) than CVD patients (0.76 [0.68 to 0.80] mm). DC, cPWV, RS, and CS did not significantly differ between groups (P > 0.05). A higher CS or RS was associated with a higher DC (CS: r = −0.32;p < 0.05 and RS: r = 0.24;p < 0.05) and lower cPWV (CS: r = 0.24;p < 0.05 and RS: r = −0.25;p < 0.05). IMT could identify CVD (AROC: 0.66, 95%-CI: 0.53 to 0.79), whilst the other measurements, alone or in combination, did not significantly increase the discriminatory power compared to IMT. Conclusions In non-stenotic arteries, compound strain imaging is feasible, but does not seem to provide incremental discriminative power to traditional measures of vascular health for differentiation between individuals with and without a history of CVD. |
topic |
Strain imaging Myocardial infarction Ultrasound imaging Cardiovascular assessment Intima media thickness |
url |
http://link.springer.com/article/10.1186/s12947-017-0104-9 |
work_keys_str_mv |
AT martijnfhmaessen feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols AT thijsmheijsvogels feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols AT aylagrotens feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols AT mariatehopman feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols AT dickhjthijssen feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols AT hendrikhghansen feasibilityandrelevanceofcompoundstrainimaginginnonstenoticarteriescomparisonbetweenindividualswithcardiovasculardiseasesandhealthycontrols |
_version_ |
1725467765732540416 |