Case Report: Amyloid-Producing Odontogenic Tumor With Pulmonary Metastasis in a Spinone Italiano—Proof of Malignant Potential

• Main Authors: Callie Blackford Winders, Cynthia M. Bell, Stephanie Goldschmidt
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-09-01
• Series: Frontiers in Veterinary Science
• Subjects: amyloid producing odontogenic tumor; odontogenic tumor; neoplasia; dogs; pathology—head and neck neoplasms
• Online Access: https://www.frontiersin.org/article/10.3389/fvets.2020.576376/full

A 1-year-old male Spinone Italiano dog was treated for an amyloid-producing odontogenic tumor on the right maxilla with a cytoreductive surgery followed by a definitive radiation protocol. Six years later, the dog presented for a new mass on the rostral mandible as well as a lung nodule without recurrence of the original maxillary tumor. Both the mandibular mass and the lung nodule were histologically confirmed to be amyloid-producing odontogenic tumor based on the appearance of sheets and cords of the odontogenic epithelium disrupted by amorphous extracellular amyloid. This case illustrates the metastatic potential for amyloid-producing odontogenic tumor in dogs and asynchronous occurrence of multiple APOTs in the oral cavity.