Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer
The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA) allows to improve the sensibility of rout...
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2015-09-01
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doaj-070ae78cec2f49c2abb24dd07bbb9fce2021-07-29T08:06:57ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322015-09-0143293510.24931/2413-9432-2015-4-3-29-3574Fluorescence cystoscopy in patients with non-muscle invasive bladder cancerI. G. Rusakov0A. A. Teplov1R. V. Ulianov2E. V. Filonenko3SBEI of HPE « I.M. Sechenov First Moscow State Medical University», Moscow, RussiaFSBI «A.V. Vishnevsky Institute of Surgery», Moscow, RussiaP.A. Herzen MCRI (branch of FSBI «NMRRC» of the Ministry of Health of the Russian Federation), Moscow, RussiaP.A. Herzen MCRI (branch of FSBI «NMRRC» of the Ministry of Health of the Russian Federation), Moscow, Russia SBEI of HPE « I.M. Sechenov First Moscow State Medical University», Moscow, RussiaThe main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA) allows to improve the sensibility of routine cystoscopy, but low specificity decreases its diagnostic accuracy. The method of fluorescence imaging combined with local fluorescence spectroscopy developed in P.A. Herzen MCRI has been shown to increase the specificity from 71% to 84%. Thus, local fluorescence spectroscopy in visible fluorescence of 5-ALA-induced protoporphyrin allows to perform guided biopsy and decrease the rate of diagnostic mistakes.https://www.pdt-journal.com/jour/article/view/76fluorescence diagnosislocal fluorescence spectroscopybladder cancer5-aminolevulinic acid |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. G. Rusakov A. A. Teplov R. V. Ulianov E. V. Filonenko |
spellingShingle |
I. G. Rusakov A. A. Teplov R. V. Ulianov E. V. Filonenko Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer Biomedical Photonics fluorescence diagnosis local fluorescence spectroscopy bladder cancer 5-aminolevulinic acid |
author_facet |
I. G. Rusakov A. A. Teplov R. V. Ulianov E. V. Filonenko |
author_sort |
I. G. Rusakov |
title |
Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
title_short |
Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
title_full |
Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
title_fullStr |
Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
title_full_unstemmed |
Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
title_sort |
fluorescence cystoscopy in patients with non-muscle invasive bladder cancer |
publisher |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
series |
Biomedical Photonics |
issn |
2413-9432 |
publishDate |
2015-09-01 |
description |
The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA) allows to improve the sensibility of routine cystoscopy, but low specificity decreases its diagnostic accuracy. The method of fluorescence imaging combined with local fluorescence spectroscopy developed in P.A. Herzen MCRI has been shown to increase the specificity from 71% to 84%. Thus, local fluorescence spectroscopy in visible fluorescence of 5-ALA-induced protoporphyrin allows to perform guided biopsy and decrease the rate of diagnostic mistakes. |
topic |
fluorescence diagnosis local fluorescence spectroscopy bladder cancer 5-aminolevulinic acid |
url |
https://www.pdt-journal.com/jour/article/view/76 |
work_keys_str_mv |
AT igrusakov fluorescencecystoscopyinpatientswithnonmuscleinvasivebladdercancer AT aateplov fluorescencecystoscopyinpatientswithnonmuscleinvasivebladdercancer AT rvulianov fluorescencecystoscopyinpatientswithnonmuscleinvasivebladdercancer AT evfilonenko fluorescencecystoscopyinpatientswithnonmuscleinvasivebladdercancer |
_version_ |
1721257856012910592 |