Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer

• Main Authors: I. G. Rusakov, A. A. Teplov, R. V. Ulianov, E. V. Filonenko
• Format: Article
• Language: Russian
• Published: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" 2015-09-01
• Series: Biomedical Photonics
• Subjects: fluorescence diagnosis; local fluorescence spectroscopy; bladder cancer; 5-aminolevulinic acid
• Online Access: https://www.pdt-journal.com/jour/article/view/76

The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with 5-aminolevulinic acid (5-ALA) allows to improve the sensibility of routine cystoscopy, but low specificity decreases its diagnostic accuracy. The method of fluorescence imaging combined with local fluorescence spectroscopy developed in P.A. Herzen MCRI has been shown to increase the specificity from 71% to 84%. Thus, local fluorescence spectroscopy in visible fluorescence of 5-ALA-induced protoporphyrin allows to perform guided biopsy and decrease the rate of diagnostic mistakes.