Insights into the role of the habenular circadian clock in addiction
Drug addiction is a brain disease involving alterations in anatomy and functional neural communication. Drug intake and toxicity show daily rhythms in both humans and rodents. Evidence concerning the role of clock genes in drug intake has been previously reported. However, the implication of a timek...
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doaj-070b9a82bb4440aea2b4586eb4003d892020-11-24T23:04:42ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402016-01-01610.3389/fpsyt.2015.00179165522Insights into the role of the habenular circadian clock in addictionNora L Salaberry0Jorge eMENDOZA1CNRS UPR3212CNRS UPR3212Drug addiction is a brain disease involving alterations in anatomy and functional neural communication. Drug intake and toxicity show daily rhythms in both humans and rodents. Evidence concerning the role of clock genes in drug intake has been previously reported. However, the implication of a timekeeping brain locus is much less known. The epithalamic lateral habenula (LHb) is now emerging as a key nucleus in drug intake and addiction. This brain structure modulates the activity of dopaminergic neurons from the ventral tegmental area, a central part of the reward system. Moreover, the LHb has circadian properties: LHb cellular activity (i.e., firing rate and clock genes expression) oscillates in a 24h range, and the nucleus is affected by photic stimulation and has anatomical connections with the main circadian pacemaker, the suprachiasmatic nucleus. Here, we describe the current insights on the role of the LHb as a circadian oscillator and its possible implications on the rhythmic regulation of the dopaminergic activity and drug intake. This data could inspire new strategies to treat drug addiction, considering circadian timing as a principal factor.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00179/fullDopamineHabenulaAddictionCircadian systemDrug of abuse |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nora L Salaberry Jorge eMENDOZA |
spellingShingle |
Nora L Salaberry Jorge eMENDOZA Insights into the role of the habenular circadian clock in addiction Frontiers in Psychiatry Dopamine Habenula Addiction Circadian system Drug of abuse |
author_facet |
Nora L Salaberry Jorge eMENDOZA |
author_sort |
Nora L Salaberry |
title |
Insights into the role of the habenular circadian clock in addiction |
title_short |
Insights into the role of the habenular circadian clock in addiction |
title_full |
Insights into the role of the habenular circadian clock in addiction |
title_fullStr |
Insights into the role of the habenular circadian clock in addiction |
title_full_unstemmed |
Insights into the role of the habenular circadian clock in addiction |
title_sort |
insights into the role of the habenular circadian clock in addiction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2016-01-01 |
description |
Drug addiction is a brain disease involving alterations in anatomy and functional neural communication. Drug intake and toxicity show daily rhythms in both humans and rodents. Evidence concerning the role of clock genes in drug intake has been previously reported. However, the implication of a timekeeping brain locus is much less known. The epithalamic lateral habenula (LHb) is now emerging as a key nucleus in drug intake and addiction. This brain structure modulates the activity of dopaminergic neurons from the ventral tegmental area, a central part of the reward system. Moreover, the LHb has circadian properties: LHb cellular activity (i.e., firing rate and clock genes expression) oscillates in a 24h range, and the nucleus is affected by photic stimulation and has anatomical connections with the main circadian pacemaker, the suprachiasmatic nucleus. Here, we describe the current insights on the role of the LHb as a circadian oscillator and its possible implications on the rhythmic regulation of the dopaminergic activity and drug intake. This data could inspire new strategies to treat drug addiction, considering circadian timing as a principal factor. |
topic |
Dopamine Habenula Addiction Circadian system Drug of abuse |
url |
http://journal.frontiersin.org/Journal/10.3389/fpsyt.2015.00179/full |
work_keys_str_mv |
AT noralsalaberry insightsintotheroleofthehabenularcircadianclockinaddiction AT jorgeemendoza insightsintotheroleofthehabenularcircadianclockinaddiction |
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1725629074049597440 |