The diagnostic value of lymph node biopsy to detect Castleman’s disease
HIV is not indicated in the aetiology of Castleman’s disease. However, it impacts on the prevalence and natural history of this disease and significantly on the disease progression. Castleman’s disease is a uni- or multicentric disease of the lymph node with or without polyclonal proliferation of B-...
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doaj-070c646acf424700a161fcc4a67565ab2020-11-24T21:57:49ZengAOSISSouthern African Journal of HIV Medicine1608-96932078-67512014-09-0115311011110.4102/sajhivmed.v15i3.1212The diagnostic value of lymph node biopsy to detect Castleman’s diseasePrashilla Soma0Sita Kara1Department of Physiology, Faculty of Health Sciences, University of Pretoria, South AfricaDepartment of Internal Medicine, Faculty of Health Sciences, University of Pretoria, South AfricaHIV is not indicated in the aetiology of Castleman’s disease. However, it impacts on the prevalence and natural history of this disease and significantly on the disease progression. Castleman’s disease is a uni- or multicentric disease of the lymph node with or without polyclonal proliferation of B-cells. It is a morphologically distinct form of lymph node hyperplasia and is characterised by significant architectural changes in all lymphatic compartments. Histopathologically, the disease is classified into two major subtypes: the hyaline-vascular type and the plasma-cell type. A mixed type is also identified, as there are frequent transitions between the types. The diagnosis of Castleman’s disease needs to be made histologically. Treatment modalities include surgery, which is curative for unicentric disease, and systemic therapy, which is needed for multicentric disease. This case highlights the diagnostic value of lymph node excision biopsy in HIV-infected patients.https://sajhivmed.org.za/index.php/hivmed/article/view/12HIVLymph node biopsyCastleman's disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Prashilla Soma Sita Kara |
spellingShingle |
Prashilla Soma Sita Kara The diagnostic value of lymph node biopsy to detect Castleman’s disease Southern African Journal of HIV Medicine HIV Lymph node biopsy Castleman's disease |
author_facet |
Prashilla Soma Sita Kara |
author_sort |
Prashilla Soma |
title |
The diagnostic value of lymph node biopsy to detect Castleman’s disease |
title_short |
The diagnostic value of lymph node biopsy to detect Castleman’s disease |
title_full |
The diagnostic value of lymph node biopsy to detect Castleman’s disease |
title_fullStr |
The diagnostic value of lymph node biopsy to detect Castleman’s disease |
title_full_unstemmed |
The diagnostic value of lymph node biopsy to detect Castleman’s disease |
title_sort |
diagnostic value of lymph node biopsy to detect castleman’s disease |
publisher |
AOSIS |
series |
Southern African Journal of HIV Medicine |
issn |
1608-9693 2078-6751 |
publishDate |
2014-09-01 |
description |
HIV is not indicated in the aetiology of Castleman’s disease. However, it impacts on the prevalence and natural history of this disease and significantly on the disease progression. Castleman’s disease is a uni- or multicentric disease of the lymph node with or without polyclonal proliferation of B-cells. It is a morphologically distinct form of lymph node hyperplasia and is characterised by significant architectural changes in all lymphatic compartments. Histopathologically, the disease is classified into two major subtypes: the hyaline-vascular type and the plasma-cell type. A mixed type is also identified, as there are frequent transitions between the types. The diagnosis of Castleman’s disease needs to be made histologically. Treatment modalities include surgery, which is curative for unicentric disease, and systemic therapy, which is needed for multicentric disease. This case highlights the diagnostic value of lymph node excision biopsy in HIV-infected patients. |
topic |
HIV Lymph node biopsy Castleman's disease |
url |
https://sajhivmed.org.za/index.php/hivmed/article/view/12 |
work_keys_str_mv |
AT prashillasoma thediagnosticvalueoflymphnodebiopsytodetectcastlemansdisease AT sitakara thediagnosticvalueoflymphnodebiopsytodetectcastlemansdisease AT prashillasoma diagnosticvalueoflymphnodebiopsytodetectcastlemansdisease AT sitakara diagnosticvalueoflymphnodebiopsytodetectcastlemansdisease |
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1725853267559186432 |