In Vitro Comparison of Different Brands of Cetirizine 2HCl Tablets by Spectroscopy and Thin Layer Chromatography (TLC) in Local Market of Lahore, Pakistan

• Main Authors: Ammara Rafiq, Zaheer Ahmad, Muhammad Ajmal
• Format: Article
• Language: English
• Published: Ptolemy Scientific Research Press 2018-11-01
• Series: Engineering and Applied Science Letters
• Subjects: cetirizine 2hcl; comparative analysis; spectroscopy; tlc; physiochemical parameters.
• Online Access: https://pisrt.org/psr-press/journals/easl-vol-1-issue-2-2018/in-vitro-comparison-of-different-brands-of-cetirizine-2hcl-tablets-by-spectroscopy-and-thin-layer-chromatography-tlc-in-local-market-of-lahore-pakistan/
• ISSN: 2617-9695; 2617-9709

The objective of the present study was to investigate and compare the efficacy, physiochemical equivalence and purity of API’s of different brands of cetirizine 2HCl tablets (10mg) with that of multinational brands available in local market of Lahore, Pakistan. The present work also provides awareness to allergy patients about most effective local brands with reasonable prices, without any health risk. Spectrophotometric method was used for chemical assay, TLC technique was subjected for the purity of API’s and physiochemical parameters was employed i.e; weight variation, hardness, friability, thickness, disintegration time and dissolution study as well as price fluctuation in PK rupees. The results of all physiochemical parameters and chemical assay were found to be within limit and meet to the pharmacopeial standards. TLC technique was developed to check the quality and purity of API, all the active ingredients showed the similar \(R_f\)-values without any impurity (0.38-0.39). From the test results and plots, it was observed and concluded that an economical and quality products can be prescribed for allergy patients whether they are manufactured by the local or multinational pharmaceutical companies without any health risk.