Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...

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Main Authors: Heloisa B Gabriel, Mauro F Azevedo, Emília A Kimura, Alejandro M Katzin
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2018-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en
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spelling doaj-070f78d6ac6e47c78c42ae26b0270cfd2020-11-25T02:34:43ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602018-08-011131010.1590/0074-02760180174S0074-02762018001000400Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronateHeloisa B GabrielMauro F AzevedoEmília A KimuraAlejandro M KatzinFarnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=enP. falciparumFPPS/GGPPSrisedronateoverexpression
collection DOAJ
language English
format Article
sources DOAJ
author Heloisa B Gabriel
Mauro F Azevedo
Emília A Kimura
Alejandro M Katzin
spellingShingle Heloisa B Gabriel
Mauro F Azevedo
Emília A Kimura
Alejandro M Katzin
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
Memórias do Instituto Oswaldo Cruz.
P. falciparum
FPPS/GGPPS
risedronate
overexpression
author_facet Heloisa B Gabriel
Mauro F Azevedo
Emília A Kimura
Alejandro M Katzin
author_sort Heloisa B Gabriel
title Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_short Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_full Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_fullStr Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_full_unstemmed Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
title_sort plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
publisher Instituto Oswaldo Cruz, Ministério da Saúde
series Memórias do Instituto Oswaldo Cruz.
issn 1678-8060
publishDate 2018-08-01
description Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.
topic P. falciparum
FPPS/GGPPS
risedronate
overexpression
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en
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