Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FP...
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Instituto Oswaldo Cruz, Ministério da Saúde
2018-08-01
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doaj-070f78d6ac6e47c78c42ae26b0270cfd2020-11-25T02:34:43ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-80602018-08-011131010.1590/0074-02760180174S0074-02762018001000400Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronateHeloisa B GabrielMauro F AzevedoEmília A KimuraAlejandro M KatzinFarnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=enP. falciparumFPPS/GGPPSrisedronateoverexpression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin |
spellingShingle |
Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate Memórias do Instituto Oswaldo Cruz. P. falciparum FPPS/GGPPS risedronate overexpression |
author_facet |
Heloisa B Gabriel Mauro F Azevedo Emília A Kimura Alejandro M Katzin |
author_sort |
Heloisa B Gabriel |
title |
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
title_short |
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
title_full |
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
title_fullStr |
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
title_full_unstemmed |
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
title_sort |
plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
1678-8060 |
publishDate |
2018-08-01 |
description |
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs. |
topic |
P. falciparum FPPS/GGPPS risedronate overexpression |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001000400&lng=en&tlng=en |
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