Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives

A series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by the condensation of oxazolinone derivatives (2a–c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4, 6 and 7) were prepared via acetylation of compounds 3 and 5 with acetic anhydride and chloroacetyl chl...

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Main Authors:	Heba A. El-Hady, Samar A. Abubshait
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Arabian Journal of Chemistry
Subjects:	Imidazolinone Benzoxazole Anticancer evaluation against MCF-7 and HePG2 cell lines
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535214000823

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spelling	doaj-07169a3294b54bb8a14615dfb70d25362020-11-24T22:42:30ZengElsevierArabian Journal of Chemistry1878-53522017-05-0110S2S3725S373110.1016/j.arabjc.2014.05.006Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivativesHeba A. El-Hady0Samar A. Abubshait1Chemistry Department, Faculty of Science (for Girls), Al-Azhar University, Nasr City, EgyptChemistry Department, Girls College of Science, University of Dammam, Dammam, Saudi ArabiaA series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by the condensation of oxazolinone derivatives (2a–c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4, 6 and 7) were prepared via acetylation of compounds 3 and 5 with acetic anhydride and chloroacetyl chloride. The results revealed that imidazolinone and benzoxazole derivatives are potent against the cancer cell lines MCF-7 and HePG2. In particular, benzoxazole derivatives are more potent than imidazolinone derivatives.http://www.sciencedirect.com/science/article/pii/S1878535214000823ImidazolinoneBenzoxazoleAnticancer evaluation against MCF-7 and HePG2 cell lines
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Heba A. El-Hady Samar A. Abubshait
spellingShingle	Heba A. El-Hady Samar A. Abubshait Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives Arabian Journal of Chemistry Imidazolinone Benzoxazole Anticancer evaluation against MCF-7 and HePG2 cell lines
author_facet	Heba A. El-Hady Samar A. Abubshait
author_sort	Heba A. El-Hady
title	Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
title_short	Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
title_full	Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
title_fullStr	Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
title_full_unstemmed	Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
title_sort	synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives
publisher	Elsevier
series	Arabian Journal of Chemistry
issn	1878-5352
publishDate	2017-05-01
description	A series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by the condensation of oxazolinone derivatives (2a–c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4, 6 and 7) were prepared via acetylation of compounds 3 and 5 with acetic anhydride and chloroacetyl chloride. The results revealed that imidazolinone and benzoxazole derivatives are potent against the cancer cell lines MCF-7 and HePG2. In particular, benzoxazole derivatives are more potent than imidazolinone derivatives.
topic	Imidazolinone Benzoxazole Anticancer evaluation against MCF-7 and HePG2 cell lines
url	http://www.sciencedirect.com/science/article/pii/S1878535214000823
work_keys_str_mv	AT hebaaelhady synthesisandanticancerevaluationofimidazolinoneandbenzoxazolederivatives AT samaraabubshait synthesisandanticancerevaluationofimidazolinoneandbenzoxazolederivatives
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Synthesis and anticancer evaluation of imidazolinone and benzoxazole derivatives

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