Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development

Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development

Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snak...

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Main Authors: Huixiang Xiao, Hong Pan, Keren Liao, Mengxue Yang, Chunhong Huang
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/6592820
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spelling doaj-071fd57e4ec447388a2ada7f5f2c50302020-11-24T21:57:47ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/65928206592820Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug DevelopmentHuixiang Xiao0Hong Pan1Keren Liao2Mengxue Yang3Chunhong Huang4Department of Biochemistry, College of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, ChinaDepartment of Biochemistry, College of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, ChinaDepartment of Biochemistry, College of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, ChinaDepartment of Biochemistry, College of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, ChinaDepartment of Biochemistry, College of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, ChinaSnakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price. Snake venom phospholipase A2s (svPLA2s) are found in all kinds of venomous snake families (e.g., Viperidae, Elapidae, and Colubridae). Along with their catalytic activity, svPLA2s elicit a wide variety of pharmacological effects that play a pivotal role in envenomation damage. Hence, neutralization of the svPLA2s could weaken or inhibit toxic damage. Here we overviewed the latest knowledge on the distribution, pathophysiological effects, and inhibitors of svPLA2s to elucidate the potential for a novel, wide spectrum antivenom drug targeting svPLA2s.http://dx.doi.org/10.1155/2017/6592820
collection DOAJ
language English
format Article
sources DOAJ
author Huixiang Xiao
Hong Pan
Keren Liao
Mengxue Yang
Chunhong Huang
spellingShingle Huixiang Xiao
Hong Pan
Keren Liao
Mengxue Yang
Chunhong Huang
Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
BioMed Research International
author_facet Huixiang Xiao
Hong Pan
Keren Liao
Mengxue Yang
Chunhong Huang
author_sort Huixiang Xiao
title Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
title_short Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
title_full Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
title_fullStr Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
title_full_unstemmed Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
title_sort snake venom pla2, a promising target for broad-spectrum antivenom drug development
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price. Snake venom phospholipase A2s (svPLA2s) are found in all kinds of venomous snake families (e.g., Viperidae, Elapidae, and Colubridae). Along with their catalytic activity, svPLA2s elicit a wide variety of pharmacological effects that play a pivotal role in envenomation damage. Hence, neutralization of the svPLA2s could weaken or inhibit toxic damage. Here we overviewed the latest knowledge on the distribution, pathophysiological effects, and inhibitors of svPLA2s to elucidate the potential for a novel, wide spectrum antivenom drug targeting svPLA2s.
url http://dx.doi.org/10.1155/2017/6592820
work_keys_str_mv AT huixiangxiao snakevenompla2apromisingtargetforbroadspectrumantivenomdrugdevelopment
AT hongpan snakevenompla2apromisingtargetforbroadspectrumantivenomdrugdevelopment
AT kerenliao snakevenompla2apromisingtargetforbroadspectrumantivenomdrugdevelopment
AT mengxueyang snakevenompla2apromisingtargetforbroadspectrumantivenomdrugdevelopment
AT chunhonghuang snakevenompla2apromisingtargetforbroadspectrumantivenomdrugdevelopment
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