Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL

Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL

Endothelial lipase (EL) is a strong modulator of the high-density lipoprotein (HDL) structure, composition, and function. Here, we examined the impact of EL on HDL paraoxonase 1 (PON1) content and arylesterase (AE) activity in vitro and in vivo. The incubation of HDL with EL-overexpressing HepG2 cel...

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Bibliographic Details
Main Authors: Irene Schilcher, Julia T. Stadler, Margarete Lechleitner, Andelko Hrzenjak, Andrea Berghold, Gudrun Pregartner, Marie Lhomme, Michael Holzer, Melanie Korbelius, Florian Reichmann, Anna Springer, Christian Wadsack, Tobias Madl, Dagmar Kratky, Anatol Kontush, Gunther Marsche, Saša Frank
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial lipase
high-density lipoprotein
paraoxonase 1
arylesterase activity
mass spectrometry
NMR spectroscopy
Online Access:https://www.mdpi.com/1422-0067/22/2/719

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