| Summary: | This paper describes the results obtained when the characteristics of metabolic process changes in leukemia, including brucellosis-complicated leukemia, were studied. To do it, 50 blood serum samples were taken from cows with specific antibodies against bovine leukemia virus (BLV) under the results of immunological diffusion reactions (IDR), indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA). All samples were serologically tested to detect a number of bacterial infections resulted in a possibility to establish that the BLV carrier state in most animals is combined with a bacterial infection, especially brucellosis (46%), chlamydia (20%), paratuberculosis (12%) and campylobacteriosis (8 %). At the next stage, 3 groups of 10 animals each were formed to study the metabolic process level, i.e. clinical healthy animals with no specific antibodies revealed during diagnostic tests for leukemia and other infections (Group 1); BLV carriers (Group 2); brucellosisand virus carrier animals (Group 3). Analysis of the blood chemistry values obtained for the experimental groups showed an uneven path of changes, especially for the protein and fat metabolism parameters. The difference was in albumin and cholesterol concentrations reduced in BLV infected animals, while their level was significantly increased in animals with leukemia associated with brucellosis, on the contrary.
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