Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches
Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide and was estimated to result in 782,000 deaths in 2018. Challenges exis...
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doaj-07309267497f431c9b6a107d171d32dc2020-11-25T01:40:48ZengMDPI AGCancers2072-66942020-03-0112359210.3390/cancers12030592cancers12030592Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic ApproachesAravind Sanjeevaiah0Haeseong Park1Benjamin Fangman2Matthew Porembka3Department of Medicine, University of Texas at Southwestern, Dallas, TX 75390, USADepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USADepartment of Medicine, University of Texas at Southwestern, Dallas, TX 75390, USADepartment of Surgery, University of Texas at Southwestern, Dallas, TX 75390, USAGastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide and was estimated to result in 782,000 deaths in 2018. Challenges exist in accurately assessing the disease burden, as available radiological staging often underestimates metastatic disease. This diagnostic handicap, along with the poor understanding of the heterogeneous biology of gastric cancer, has hindered the development of effective therapeutic solutions and thus halted improvement in patient outcomes over the last few decades. The management of occult peritoneal disease is complicated, as most patients are understaged by standard imaging studies and therefore thought to have local diseases. In this article, we systematically review recent literature on the limitations that are associated with standard radiographic staging, discuss recent molecular biology advances to better identify and diagnose occult peritoneal disease, and propose possible management strategies to approach this complicated clinical problem.https://www.mdpi.com/2072-6694/12/3/592gastric cancerperitoneal diseasectdnastaging laparoscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aravind Sanjeevaiah Haeseong Park Benjamin Fangman Matthew Porembka |
spellingShingle |
Aravind Sanjeevaiah Haeseong Park Benjamin Fangman Matthew Porembka Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches Cancers gastric cancer peritoneal disease ctdna staging laparoscopy |
author_facet |
Aravind Sanjeevaiah Haeseong Park Benjamin Fangman Matthew Porembka |
author_sort |
Aravind Sanjeevaiah |
title |
Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches |
title_short |
Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches |
title_full |
Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches |
title_fullStr |
Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches |
title_full_unstemmed |
Gastric Cancer with Radiographically Occult Metastatic Disease: Biology, Challenges, and Diagnostic Approaches |
title_sort |
gastric cancer with radiographically occult metastatic disease: biology, challenges, and diagnostic approaches |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-03-01 |
description |
Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide and was estimated to result in 782,000 deaths in 2018. Challenges exist in accurately assessing the disease burden, as available radiological staging often underestimates metastatic disease. This diagnostic handicap, along with the poor understanding of the heterogeneous biology of gastric cancer, has hindered the development of effective therapeutic solutions and thus halted improvement in patient outcomes over the last few decades. The management of occult peritoneal disease is complicated, as most patients are understaged by standard imaging studies and therefore thought to have local diseases. In this article, we systematically review recent literature on the limitations that are associated with standard radiographic staging, discuss recent molecular biology advances to better identify and diagnose occult peritoneal disease, and propose possible management strategies to approach this complicated clinical problem. |
topic |
gastric cancer peritoneal disease ctdna staging laparoscopy |
url |
https://www.mdpi.com/2072-6694/12/3/592 |
work_keys_str_mv |
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