Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery
Abstract Background Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute...
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doaj-0732f80f4c0e4ec7b17b9d133c918c742020-11-25T00:42:31ZengBMCBMC Nephrology1471-23692018-10-011911910.1186/s12882-018-1093-0Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgeryMoritz Wyler von Ballmoos0Donald S. Likosky1Michael Rezaee2Kevin Lobdell3Shama Alam4Devin Parker5Sherry Owens6Heather Thiessen-Philbrook7Todd MacKenzie8Jeremiah R. Brown9Division of Cardiovascular and Thoracic Surgery, Duke University Medical CenterInstitute for Healthcare Policy and Innovation, University of MichiganSection of Urology, Department of Surgery, Dartmouth-Hitchcock Medical CenterCarolinas HealthCare SystemThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of MedicineThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of MedicineThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of MedicineDivision of Nephrology, Department of Medicine, Johns Hopkins UniversityThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of MedicineThe Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of MedicineAbstract Background Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. Methods Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007. Preoperative Gal-3 levels were measured using multiplex assays and grouped into terciles. Univariate and multinomial logistic regression was used to assess the predictive ability of Gal-3 terciles and AKI occurrence and severity. Results Before adjustment, patients in the highest tercile of Gal-3 had a 2.86-greater odds of developing postoperative KDIGO Stage 2 or 3 (p < 0.001) and 1.70-greater odds of developing KDIGO Stage 1 (p = < 0.001), compared to the first tercile. After adjustment, patients in the highest tercile had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the first tercile. Compared to the base model, the addition of Gal-3 terciles improved discriminatory power compared to without Gal-3 terciles (test of equality = 0.042). Conclusion Elevated preoperative Gal-3 levels significantly improves predictive ability over existing clinical models for postoperative AKI and may be used to augment risk information for patients at the highest risk of developing AKI and AKI severity after cardiac surgery.http://link.springer.com/article/10.1186/s12882-018-1093-0Acute kidney injury (AKI)Galectin-3 (Gal-3)Cardiac surgeryPredictionBiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moritz Wyler von Ballmoos Donald S. Likosky Michael Rezaee Kevin Lobdell Shama Alam Devin Parker Sherry Owens Heather Thiessen-Philbrook Todd MacKenzie Jeremiah R. Brown |
spellingShingle |
Moritz Wyler von Ballmoos Donald S. Likosky Michael Rezaee Kevin Lobdell Shama Alam Devin Parker Sherry Owens Heather Thiessen-Philbrook Todd MacKenzie Jeremiah R. Brown Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery BMC Nephrology Acute kidney injury (AKI) Galectin-3 (Gal-3) Cardiac surgery Prediction Biomarkers |
author_facet |
Moritz Wyler von Ballmoos Donald S. Likosky Michael Rezaee Kevin Lobdell Shama Alam Devin Parker Sherry Owens Heather Thiessen-Philbrook Todd MacKenzie Jeremiah R. Brown |
author_sort |
Moritz Wyler von Ballmoos |
title |
Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery |
title_short |
Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery |
title_full |
Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery |
title_fullStr |
Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery |
title_full_unstemmed |
Elevated preoperative Galectin-3 is associated with acute kidney injury after cardiac surgery |
title_sort |
elevated preoperative galectin-3 is associated with acute kidney injury after cardiac surgery |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2018-10-01 |
description |
Abstract Background Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship between preoperative levels of circulating Galectin-3 (Gal-3) and acute kidney injury after cardiac surgery. Methods Preoperative serum Gal-3 was measured in 1498 patients who underwent coronary artery bypass graft (CABG) surgery and/or valve surgery as part of the Northern New England Biomarker Study between 2004 and 2007. Preoperative Gal-3 levels were measured using multiplex assays and grouped into terciles. Univariate and multinomial logistic regression was used to assess the predictive ability of Gal-3 terciles and AKI occurrence and severity. Results Before adjustment, patients in the highest tercile of Gal-3 had a 2.86-greater odds of developing postoperative KDIGO Stage 2 or 3 (p < 0.001) and 1.70-greater odds of developing KDIGO Stage 1 (p = < 0.001), compared to the first tercile. After adjustment, patients in the highest tercile had 2.95-greater odds of developing KDIGO Stage 2 or 3 (p < 0.001) and 1.71-increased odds of developing KDIGO Stage 1 (p = 0.001), compared to the first tercile. Compared to the base model, the addition of Gal-3 terciles improved discriminatory power compared to without Gal-3 terciles (test of equality = 0.042). Conclusion Elevated preoperative Gal-3 levels significantly improves predictive ability over existing clinical models for postoperative AKI and may be used to augment risk information for patients at the highest risk of developing AKI and AKI severity after cardiac surgery. |
topic |
Acute kidney injury (AKI) Galectin-3 (Gal-3) Cardiac surgery Prediction Biomarkers |
url |
http://link.springer.com/article/10.1186/s12882-018-1093-0 |
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