Vaccination as a preventative measure contributing to immune fitness
Abstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unre...
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Nature Publishing Group
2021-07-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-021-00354-z |
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doaj-07346b6c4d044d88ad114ce7ad6a5c8b2021-08-01T11:06:22ZengNature Publishing Groupnpj Vaccines2059-01052021-07-016111010.1038/s41541-021-00354-zVaccination as a preventative measure contributing to immune fitnessBéatrice Laupèze0Giuseppe Del Giudice1Mark T. Doherty2Robbert Van der Most3GSKGSKGSKGSKAbstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of “immune fitness” and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging.https://doi.org/10.1038/s41541-021-00354-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most |
spellingShingle |
Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most Vaccination as a preventative measure contributing to immune fitness npj Vaccines |
author_facet |
Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most |
author_sort |
Béatrice Laupèze |
title |
Vaccination as a preventative measure contributing to immune fitness |
title_short |
Vaccination as a preventative measure contributing to immune fitness |
title_full |
Vaccination as a preventative measure contributing to immune fitness |
title_fullStr |
Vaccination as a preventative measure contributing to immune fitness |
title_full_unstemmed |
Vaccination as a preventative measure contributing to immune fitness |
title_sort |
vaccination as a preventative measure contributing to immune fitness |
publisher |
Nature Publishing Group |
series |
npj Vaccines |
issn |
2059-0105 |
publishDate |
2021-07-01 |
description |
Abstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of “immune fitness” and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging. |
url |
https://doi.org/10.1038/s41541-021-00354-z |
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