HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth

Hypoxia-inducible gene domain family member 1A (HIGD1A) is a survival factor induced by hypoxia-inducible factor 1 (HIF-1). HIF-1 regulates many responses to oxygen deprivation, but viable cells within hypoxic perinecrotic solid tumor regions frequently lack HIF-1α. HIGD1A is induced in these HIF-de...

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Main Authors:	Kurosh Ameri, Arman Jahangiri, Anthony M. Rajah, Kathryn V. Tormos, Ravi Nagarajan, Melike Pekmezci, Vien Nguyen, Matthew L. Wheeler, Michael P. Murphy, Timothy A. Sanders, Stefanie S. Jeffrey, Yerem Yeghiazarians, Paolo F. Rinaudo, Joseph F. Costello, Manish K. Aghi, Emin Maltepe
Format:	Article
Language:	English
Published:	Elsevier 2015-02-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715000339

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spelling	doaj-073f933d7346420aa940bda4e626e3d62020-11-24T21:34:06ZengElsevierCell Reports2211-12472015-02-0110689189910.1016/j.celrep.2015.01.020HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor GrowthKurosh Ameri0Arman Jahangiri1Anthony M. Rajah2Kathryn V. Tormos3Ravi Nagarajan4Melike Pekmezci5Vien Nguyen6Matthew L. Wheeler7Michael P. Murphy8Timothy A. Sanders9Stefanie S. Jeffrey10Yerem Yeghiazarians11Paolo F. Rinaudo12Joseph F. Costello13Manish K. Aghi14Emin Maltepe15Department of Pediatrics/Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USADepartment of Pediatrics/Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Pediatrics/Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USADepartment of Pathology, University of California San Francisco, San Francisco, CA 94143, USADepartment of Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Microbiology/Immunology, University of California San Francisco, San Francisco, CA 94143, USAMitochondrial Biology Unit, MRC, Cambridge CB2 0XY, UKDepartment of Pediatrics/Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Medicine/CVRI/Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA 94143, USADepartment of Obstetrics, Gynecology/Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USADepartment of Pediatrics/Biomedical Sciences, University of California San Francisco, San Francisco, CA 94143, USAHypoxia-inducible gene domain family member 1A (HIGD1A) is a survival factor induced by hypoxia-inducible factor 1 (HIF-1). HIF-1 regulates many responses to oxygen deprivation, but viable cells within hypoxic perinecrotic solid tumor regions frequently lack HIF-1α. HIGD1A is induced in these HIF-deficient extreme environments and interacts with the mitochondrial electron transport chain to repress oxygen consumption, enhance AMPK activity, and lower cellular ROS levels. Importantly, HIGD1A decreases tumor growth but promotes tumor cell survival in vivo. The human Higd1a gene is located on chromosome 3p22.1, where many tumor suppressor genes reside. Consistent with this, the Higd1a gene promoter is differentially methylated in human cancers, preventing its hypoxic induction. However, when hypoxic tumor cells are confronted with glucose deprivation, DNA methyltransferase activity is inhibited, enabling HIGD1A expression, metabolic adaptation, and possible dormancy induction. Our findings therefore reveal important new roles for this family of mitochondrial proteins in cancer biology.http://www.sciencedirect.com/science/article/pii/S2211124715000339
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kurosh Ameri Arman Jahangiri Anthony M. Rajah Kathryn V. Tormos Ravi Nagarajan Melike Pekmezci Vien Nguyen Matthew L. Wheeler Michael P. Murphy Timothy A. Sanders Stefanie S. Jeffrey Yerem Yeghiazarians Paolo F. Rinaudo Joseph F. Costello Manish K. Aghi Emin Maltepe
spellingShingle	Kurosh Ameri Arman Jahangiri Anthony M. Rajah Kathryn V. Tormos Ravi Nagarajan Melike Pekmezci Vien Nguyen Matthew L. Wheeler Michael P. Murphy Timothy A. Sanders Stefanie S. Jeffrey Yerem Yeghiazarians Paolo F. Rinaudo Joseph F. Costello Manish K. Aghi Emin Maltepe HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth Cell Reports
author_facet	Kurosh Ameri Arman Jahangiri Anthony M. Rajah Kathryn V. Tormos Ravi Nagarajan Melike Pekmezci Vien Nguyen Matthew L. Wheeler Michael P. Murphy Timothy A. Sanders Stefanie S. Jeffrey Yerem Yeghiazarians Paolo F. Rinaudo Joseph F. Costello Manish K. Aghi Emin Maltepe
author_sort	Kurosh Ameri
title	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
title_short	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
title_full	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
title_fullStr	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
title_full_unstemmed	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth
title_sort	higd1a regulates oxygen consumption, ros production, and ampk activity during glucose deprivation to modulate cell survival and tumor growth
publisher	Elsevier
series	Cell Reports
issn	2211-1247
publishDate	2015-02-01
description	Hypoxia-inducible gene domain family member 1A (HIGD1A) is a survival factor induced by hypoxia-inducible factor 1 (HIF-1). HIF-1 regulates many responses to oxygen deprivation, but viable cells within hypoxic perinecrotic solid tumor regions frequently lack HIF-1α. HIGD1A is induced in these HIF-deficient extreme environments and interacts with the mitochondrial electron transport chain to repress oxygen consumption, enhance AMPK activity, and lower cellular ROS levels. Importantly, HIGD1A decreases tumor growth but promotes tumor cell survival in vivo. The human Higd1a gene is located on chromosome 3p22.1, where many tumor suppressor genes reside. Consistent with this, the Higd1a gene promoter is differentially methylated in human cancers, preventing its hypoxic induction. However, when hypoxic tumor cells are confronted with glucose deprivation, DNA methyltransferase activity is inhibited, enabling HIGD1A expression, metabolic adaptation, and possible dormancy induction. Our findings therefore reveal important new roles for this family of mitochondrial proteins in cancer biology.
url	http://www.sciencedirect.com/science/article/pii/S2211124715000339
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HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth

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