MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes
The combined analysis of MEG/EEG and functional MRI measurements can lead to improvement in the description of the dynamical and spatial properties of brain activity. In this paper we empirically demonstrate this improvement using simulated and recorded task related MEG and fM...
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2010-11-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fninf.2010.00114/full |
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doaj-073ff0d888884292bd3da9c276d674f42020-11-24T21:57:49ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962010-11-01410.3389/fninf.2010.001141528MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changesSergey M Plis0Sergey M Plis1Vince D Calhoun2Vince D Calhoun3Tom Eichele4Michael P Weisend5Terran Lane6The University of New MexicoMIND Research NetworkMIND Research NetworkThe University of New MexicoUniversity of BergenMIND Research NetworkThe University of New MexicoThe combined analysis of MEG/EEG and functional MRI measurements can lead to improvement in the description of the dynamical and spatial properties of brain activity. In this paper we empirically demonstrate this improvement using simulated and recorded task related MEG and fMRI activity. Neural activity estimates were derived using a dynamic Bayesian network with continuous real valued parameters by means of a sequential Monte Carlo technique. In synthetic data, we show that MEG and fMRI fusion improves estimation of the indirectly observed neural activity and smooths tracking of the BOLD response. In recordings of task related neural activity the combination of MEG and fMRI produces a result with greater SNR, that confirms the expectation arising from the nature of the experiment. The highly nonlinear model of the BOLD response poses a difficult inference problem for neural activity estimation; computational requirements are also high due to the time and space complexity. We show that joint analysis of the data improves the system's behavior by stabilizing the differential equations system and by requiring fewer computational resources.http://journal.frontiersin.org/Journal/10.3389/fninf.2010.00114/fullDynamic Bayesian Networkslatent variable inferencemultimodal data fusionparticle filtering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sergey M Plis Sergey M Plis Vince D Calhoun Vince D Calhoun Tom Eichele Michael P Weisend Terran Lane |
spellingShingle |
Sergey M Plis Sergey M Plis Vince D Calhoun Vince D Calhoun Tom Eichele Michael P Weisend Terran Lane MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes Frontiers in Neuroinformatics Dynamic Bayesian Networks latent variable inference multimodal data fusion particle filtering |
author_facet |
Sergey M Plis Sergey M Plis Vince D Calhoun Vince D Calhoun Tom Eichele Michael P Weisend Terran Lane |
author_sort |
Sergey M Plis |
title |
MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes |
title_short |
MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes |
title_full |
MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes |
title_fullStr |
MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes |
title_full_unstemmed |
MEG and fMRI fusion for nonlinear estimation of neural and BOLD signal changes |
title_sort |
meg and fmri fusion for nonlinear estimation of neural and bold signal changes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroinformatics |
issn |
1662-5196 |
publishDate |
2010-11-01 |
description |
The combined analysis of MEG/EEG and functional MRI measurements can lead to improvement in the description of the dynamical and spatial properties of brain activity. In this paper we empirically demonstrate this improvement using simulated and recorded task related MEG and fMRI activity. Neural activity estimates were derived using a dynamic Bayesian network with continuous real valued parameters by means of a sequential Monte Carlo technique. In synthetic data, we show that MEG and fMRI fusion improves estimation of the indirectly observed neural activity and smooths tracking of the BOLD response. In recordings of task related neural activity the combination of MEG and fMRI produces a result with greater SNR, that confirms the expectation arising from the nature of the experiment. The highly nonlinear model of the BOLD response poses a difficult inference problem for neural activity estimation; computational requirements are also high due to the time and space complexity. We show that joint analysis of the data improves the system's behavior by stabilizing the differential equations system and by requiring fewer computational resources. |
topic |
Dynamic Bayesian Networks latent variable inference multimodal data fusion particle filtering |
url |
http://journal.frontiersin.org/Journal/10.3389/fninf.2010.00114/full |
work_keys_str_mv |
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