| Summary: | Yunqi Bao,1 Wei Zhang,1 Dandan Shi,2 Weili Bai,1 Dongdong He,1 Dan Wang1 1Department of Rheumatology, Xi’an Fifth Hospital, Xian, 710000, Shaanxi, People’s Republic of China; 2Department of Radiology, Xi’an Fifth Hospital, Xian, 710000, Shaanxi, People’s Republic of ChinaCorrespondence: Dan WangDepartment of Rheumatology, Xi’an Fifth Hospital, 112 Xiguanzheng Street, Lianhu District, Xian, 710000, Shaanxi, People’s Republic of ChinaEmail wdtougao2021@163.comObjective: The main aims of this study were to explore the relationships between serum tumor markers and connective tissue disease-related interstitial lung disease (CTD-ILD) and to evaluate the clinical value of tumor markers for investigating interstitial lung disease (ILD) in patients with connective tissue disease (CTD).Methods: The study included 235 patients with CTD (90 CTD without ILDs, 145 CTD-ILD). Clinical information and the levels of inflammatory and tumor markers, including carbohydrate antigen (CA) 19– 9, CA125, carcinoembryonic antigen (CEA), CA153, and cytokeratin 19 fragments (CYFRA21-1), were obtained in all the patients.Results: A significant difference between CTD with or without ILD and higher levels of tumor markers was observed in the CTD-ILD group, including CA19-9 (p< 0.001), CEA (p< 0.001), CA153 (p< 0.001), and CYFRA21-1 (p< 0.001). There was no significant difference in serum tumor marker levels in the various types of CTD (rheumatoid arthritis, systemic lupus erythematosus, Sjogren’s syndrome, inflammatory myositis, systemic sclerosis, and mixed connective tissue disease). The levels of CA153 [odds ratio (OR)=1.159] and CYFRA21-1 (OR=2.269) were clearly related to the risk of CTD-ILD. The diagnostic value of CA153 [area under receiver operating characteristic curve (AUC)=0.736] and CYFRA21-1 (AUC=0.718) was confirmed for ILDs in CTD patients, at cut-off values of 9.45 U/mL and 2.13 ng/mL, respectively.Conclusion: There is a positive correlation between serum tumor marker levels and CTD-ILD. Higher levels of CA153 and CYFRA21-1 suggest an increased risk of developing ILD and may therefore be useful as biomarkers for detecting CTD-ILD in the clinical setting.Keywords: connective tissue disease, tumor markers, interstitial lung disease
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