The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study
Abstract Background Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-11-01
|
Series: | Malaria Journal |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12936-017-2091-6 |
id |
doaj-074554c96aec47659c68e4171be04e76 |
---|---|
record_format |
Article |
spelling |
doaj-074554c96aec47659c68e4171be04e762020-11-25T00:40:34ZengBMCMalaria Journal1475-28752017-11-0116111010.1186/s12936-017-2091-6The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot studyDo Hung Son0Nguyen Thuy-Nhien1Lorenz von Seidlein2Truong Le Phuc-Nhi3Ngo Thi Phu4Nguyen Thi Kim Tuyen5Nguyen Huyen Tran6Nguyen Van Dung7Bui Van Quan8Nicholas P. J. Day9Arjen M. Dondorp10Nicholas J. White11Guy E. Thwaites12Tran Tinh Hien13Oxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol UniversityOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeBinh Phuoc Malaria Prevention and Control CenterBinh Phuoc Malaria Prevention and Control CenterMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol UniversityMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol UniversityMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol UniversityOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeOxford University Clinical Research Unit, Wellcome Trust Major Overseas ProgrammeAbstract Background Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. Methods Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine. Before returning to the forest, study participants were randomly allocated to a 3-day course of DP or placebo. Fifteen days after returning from their forest deployment the participants were tested for Plasmodium infections using uPCR. Results Prior to treatment, 30 of 150 study participants (20%) were found to be infected with Plasmodium. Seventeen days (median) after enrolment the rangers were randomized to DP or placebo 2 days before returning to forest camps where they stayed between 2 and 20 days (median 9.5 days). One ranger in the DP-prophylaxis arm and one in the placebo arm were found to be infected with Plasmodium falciparum 15 days (median) after returning from the forest. The evaluable P. falciparum isolates had molecular markers indicating resistance to artemisinins (K13-C580Y) and piperaquine (plasmepsin), but none had multiple copies of pfmdr1 associated with mefloquine resistance. Conclusion Anti-malarial prophylaxis in forest rangers is feasible. The findings of the study highlight the threat of multidrug-resistant malaria. Trial registration NCT02788864http://link.springer.com/article/10.1186/s12936-017-2091-6Plasmodium falciparumPlasmodium vivaxAn. dirusAn. maculatusAn. barbirostrisAnti-malarial resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Do Hung Son Nguyen Thuy-Nhien Lorenz von Seidlein Truong Le Phuc-Nhi Ngo Thi Phu Nguyen Thi Kim Tuyen Nguyen Huyen Tran Nguyen Van Dung Bui Van Quan Nicholas P. J. Day Arjen M. Dondorp Nicholas J. White Guy E. Thwaites Tran Tinh Hien |
spellingShingle |
Do Hung Son Nguyen Thuy-Nhien Lorenz von Seidlein Truong Le Phuc-Nhi Ngo Thi Phu Nguyen Thi Kim Tuyen Nguyen Huyen Tran Nguyen Van Dung Bui Van Quan Nicholas P. J. Day Arjen M. Dondorp Nicholas J. White Guy E. Thwaites Tran Tinh Hien The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study Malaria Journal Plasmodium falciparum Plasmodium vivax An. dirus An. maculatus An. barbirostris Anti-malarial resistance |
author_facet |
Do Hung Son Nguyen Thuy-Nhien Lorenz von Seidlein Truong Le Phuc-Nhi Ngo Thi Phu Nguyen Thi Kim Tuyen Nguyen Huyen Tran Nguyen Van Dung Bui Van Quan Nicholas P. J. Day Arjen M. Dondorp Nicholas J. White Guy E. Thwaites Tran Tinh Hien |
author_sort |
Do Hung Son |
title |
The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study |
title_short |
The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study |
title_full |
The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study |
title_fullStr |
The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study |
title_full_unstemmed |
The prevalence, incidence and prevention of Plasmodium falciparum infections in forest rangers in Bu Gia Map National Park, Binh Phuoc province, Vietnam: a pilot study |
title_sort |
prevalence, incidence and prevention of plasmodium falciparum infections in forest rangers in bu gia map national park, binh phuoc province, vietnam: a pilot study |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2017-11-01 |
description |
Abstract Background Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. Methods Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine. Before returning to the forest, study participants were randomly allocated to a 3-day course of DP or placebo. Fifteen days after returning from their forest deployment the participants were tested for Plasmodium infections using uPCR. Results Prior to treatment, 30 of 150 study participants (20%) were found to be infected with Plasmodium. Seventeen days (median) after enrolment the rangers were randomized to DP or placebo 2 days before returning to forest camps where they stayed between 2 and 20 days (median 9.5 days). One ranger in the DP-prophylaxis arm and one in the placebo arm were found to be infected with Plasmodium falciparum 15 days (median) after returning from the forest. The evaluable P. falciparum isolates had molecular markers indicating resistance to artemisinins (K13-C580Y) and piperaquine (plasmepsin), but none had multiple copies of pfmdr1 associated with mefloquine resistance. Conclusion Anti-malarial prophylaxis in forest rangers is feasible. The findings of the study highlight the threat of multidrug-resistant malaria. Trial registration NCT02788864 |
topic |
Plasmodium falciparum Plasmodium vivax An. dirus An. maculatus An. barbirostris Anti-malarial resistance |
url |
http://link.springer.com/article/10.1186/s12936-017-2091-6 |
work_keys_str_mv |
AT dohungson theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenthuynhien theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT lorenzvonseidlein theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT truonglephucnhi theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT ngothiphu theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenthikimtuyen theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenhuyentran theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenvandung theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT buivanquan theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nicholaspjday theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT arjenmdondorp theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nicholasjwhite theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT guyethwaites theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT trantinhhien theprevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT dohungson prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenthuynhien prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT lorenzvonseidlein prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT truonglephucnhi prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT ngothiphu prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenthikimtuyen prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenhuyentran prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nguyenvandung prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT buivanquan prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nicholaspjday prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT arjenmdondorp prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT nicholasjwhite prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT guyethwaites prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy AT trantinhhien prevalenceincidenceandpreventionofplasmodiumfalciparuminfectionsinforestrangersinbugiamapnationalparkbinhphuocprovincevietnamapilotstudy |
_version_ |
1725289272925224960 |