Stimulation of Natural Killer T Cells by Glycolipids
Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to extensive research by chemists and immunologists...
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doaj-075176744f39436aba9ad07d11869cfc2020-11-24T23:45:15ZengMDPI AGMolecules1420-30492013-12-011812156621568810.3390/molecules181215662molecules181215662Stimulation of Natural Killer T Cells by GlycolipidsBrian L. Anderson0Luc Teyton1Albert Bendelac2Paul B. Savage3Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USADepartment of Immunology, The Scripps Research Institute, La Jolla, CA 92602, USACommittee on Immunology and Department of Pathology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USADepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USANatural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to extensive research by chemists and immunologists to understand how glycolipids are recognized, possible responses by NKT cells, and the structural features of glycolipids necessary for stimulatory activity. The presence of this cell type in humans and most mammals suggests that it plays critical roles in antigen recognition and the interface between innate and adaptive immunity. Both endogenous and exogenous natural antigens for NKT cells have been identified, and it is likely that glycolipid antigens remain to be discovered. Multiple series of structurally varied glycolipids have been synthesized and tested for stimulatory activity. The structural features of glycolipids necessary for NKT cell stimulation are moderately well understood, and designed compounds have proven to be much more potent antigens than their natural counterparts. Nevertheless, control over NKT cell responses by designed glycolipids has not been optimized, and further research will be required to fully reveal the therapeutic potential of this cell type.http://www.mdpi.com/1420-3049/18/12/15662glycolipidnatural killer T cellcytokineinnate immunity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brian L. Anderson Luc Teyton Albert Bendelac Paul B. Savage |
spellingShingle |
Brian L. Anderson Luc Teyton Albert Bendelac Paul B. Savage Stimulation of Natural Killer T Cells by Glycolipids Molecules glycolipid natural killer T cell cytokine innate immunity |
author_facet |
Brian L. Anderson Luc Teyton Albert Bendelac Paul B. Savage |
author_sort |
Brian L. Anderson |
title |
Stimulation of Natural Killer T Cells by Glycolipids |
title_short |
Stimulation of Natural Killer T Cells by Glycolipids |
title_full |
Stimulation of Natural Killer T Cells by Glycolipids |
title_fullStr |
Stimulation of Natural Killer T Cells by Glycolipids |
title_full_unstemmed |
Stimulation of Natural Killer T Cells by Glycolipids |
title_sort |
stimulation of natural killer t cells by glycolipids |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2013-12-01 |
description |
Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to extensive research by chemists and immunologists to understand how glycolipids are recognized, possible responses by NKT cells, and the structural features of glycolipids necessary for stimulatory activity. The presence of this cell type in humans and most mammals suggests that it plays critical roles in antigen recognition and the interface between innate and adaptive immunity. Both endogenous and exogenous natural antigens for NKT cells have been identified, and it is likely that glycolipid antigens remain to be discovered. Multiple series of structurally varied glycolipids have been synthesized and tested for stimulatory activity. The structural features of glycolipids necessary for NKT cell stimulation are moderately well understood, and designed compounds have proven to be much more potent antigens than their natural counterparts. Nevertheless, control over NKT cell responses by designed glycolipids has not been optimized, and further research will be required to fully reveal the therapeutic potential of this cell type. |
topic |
glycolipid natural killer T cell cytokine innate immunity |
url |
http://www.mdpi.com/1420-3049/18/12/15662 |
work_keys_str_mv |
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