Vitamin D Receptor (VDR) Gene BsmI Polymorphisms in Lupus Nephritis

• Main Authors: Mahnaz Abbasi, Zahra Rezaieyazdi, Jalil Tavakol afshari, Mohammadreza Hatef, Maryam Sahebari
• Format: Article
• Language: fas
• Published: Vesnu Publications 2011-02-01
• Series: مجله دانشکده پزشکی اصفهان
• Subjects: Vitamin D receptor gene; BsmI; Lupus nephritis
• Online Access: http://jims.mui.ac.ir/index.php/jims/article/view/595
• ISSN: 1027-7595; 1735-854X

Background: Vitamin D has immunomodulatory function. Polymorphisms of the gene encoding the vitamin D receptor detected by BsmI may be source of diversity in its action. An association between vitamin D receptor gene BsmI polymorphisms and lupus nephritis has been reported. This study was performed to evaluate vitamin D receptor gene BsmI polymorphisms in lupus nephritis. Methods: Twenty nine patients with lupus nephritis enrolled in this study. Vitamin D receptor gene typing was performed based on polymerase chain reaction-restriction fragment length polymorphism. Finding: Vitamin D receptor genotyping of BsmI polymorphisms was 20.6% for BB, 51.7% for Bb, and 27.5% for bb without statistically significant difference (P = 0.090). In 21 patients that renal biopsy was done, the Bb genotype was the most (42.8%). There was not any correlation between renal histology and vitamin D receptor gene BsmI polymorphisms (P = 0.068). Conclusion: There was no relationship between vitamin D receptor gene BsmI polymorphisms and lupus nephritis.