Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS

Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. The pattern of lower motor neuron loss along the spinal cord follows the pattern of deposition of phosphorylated TDP-43 aggregates. The blood-spinal...

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Bibliographic Details
Main Authors: Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow, Emma Scotter
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Neuropathologica Communications
Subjects:
Blood–brain barrier
Blood-spinal cord barrier
TDP-43
ALS
Hemoglobin
Human
Online Access:https://doi.org/10.1186/s40478-021-01244-0

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