Health‐related quality of life in left ventricular assist device‐supported patients

• Main Authors: Osnat Itzhaki Ben Zadok, Binyamin Ben-Avraham, Tiny Jaarsma, Aviv Shaul, Yoav Hammer, Yaron D. Barac, Israel Mats, Orit Eldar, Miriam Abuhazira, Vicky Yaari, Dmitry Gulobov, Mastwal Mulu, Dan Aravot, Ran Kornowski, Tuvia Ben-Gal
• Format: Article
• Language: English
• Published: Wiley 2021-06-01
• Series: ESC Heart Failure
• Subjects: Quality of life; Sexual dysfunction; Left ventricular assist devices; Heart failure
• Online Access: https://doi.org/10.1002/ehf2.13282

Abstract Aims This study aimed to evaluate the different health‐related quality of life (HR‐QoL) aspects in patients with both short‐term and long‐term duration LVAD support at pre‐specified time intervals. Methods and results We performed a single‐centre HR‐QoL analysis of short‐term and long‐term LVAD‐supported patients using the short version of the Kansas City Cardiomyopathy Questionnaire (KCCQ‐12) and the Changes in Sexual Functioning Questionnaire along with a survey to evaluate patients' social and driving routines. Data were collected at baseline and at 6 or 12 month follow‐up. Included were 46 patients with a median time from LVAD implantation of 1.1 [inter‐quartile range (IQR) 0.5, 2.6] years. The median KCCQ‐12 summary score was 56 (IQR 29, 74) with most favourable scores in the symptom frequency domain [75 (IQR 50, 92)] and worse scores in the physical limitation [42 (IQR 25, 75)] and QoL [44 (IQR 25, 75)] domains. No significant changes were apparent during study follow‐up [KCCQ‐12 summary score 56 (IQR 35, 80)], and no significant correlation between the KCCQ‐12 summary score and ventricular assist device‐support duration was detected (r = −0.036, P = 0.812). Sexual dysfunction was noted across all domains with a cumulative score of 31 (IQR 22, 42). Seventy‐six per cent of patients resumed driving after LVAD implantation, and 43% of patients reported they socialize with family and friends more frequently since surgery. Conclusions Short‐term and long‐term LVAD‐supported patients had impaired HR‐QoL and sexual function at baseline and at follow‐up yet reported an improvement in social interactions and independency. A broader spectrum of patient's reported HR‐QoL measures should be integrated into the pre‐LVAD implantation assessment and preparation.