Cognitive dysfunction and its determinants in patients with neurocysticercosis
Introduction: Neurocysticercosis (NCC) is the most common parasitic infection of man. In addition to a headache, seizures, and focal deficits, this is associated with significant cognitive dysfunction. Many studies revealed that the number and location of lesions are not always responsible for cogni...
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doaj-07618c28e6864f8e82202588694dda292021-08-02T10:44:33ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762016-01-0138214214610.4103/0253-7176.178809Cognitive dysfunction and its determinants in patients with neurocysticercosisVinod VargheseSadanandavalli Retnaswami ChandraRita ChristopherJamuna RajeswaranChandrajit PrasadR SubasreeThomas Gregor IssacIntroduction: Neurocysticercosis (NCC) is the most common parasitic infection of man. In addition to a headache, seizures, and focal deficits, this is associated with significant cognitive dysfunction. Many studies revealed that the number and location of lesions are not always responsible for cognitive dysfunction. Cholinesterase and pseudocholinesterase are found in the walls of the cysticercus which could contribute to cholinergic depletion and thus cognitive dysfunction. Patients and Methods: A total of 43 patients who presented with NCC were evaluated for cognitive deficits, as well as cholinesterase levels in cerebrospinal fluid (CSF) with control CSF from patients undergoing spinal anesthesia. Blood levels of interleukin-10 and tumor necrosis factor alpha were also estimated and correlated with cognitive deficits. Results: There is a mild increase in the acetylcholinesterase in CSF of patients compared to controls, but it did not correlate with cognitive deficits. There is an increase in interleukins to a significant level which correlates with vesicular stage of the organism and cognitive impairment. The number of lesions also correlated with cognitive impairment even though the location did not. The domains of cognitive deficits seen are sustained attention, category fluency, verbal working memory, planning, set shifting, verbal learning, visual memory, and construction. Discussion and Conclusion: NCC is associated with multi-domain cognitive impairment correlates with vescicular stage, proinflammatory cytokines and number of lesions but not location, vesicular stage, and proinflammatory cytokines.http://www.ijpm.info/article.asp?issn=0253-7176;year=2016;volume=38;issue=2;spage=142;epage=146;aulast=VargheseCholinesterase levelscognitive dysfunctionneurocysticercosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vinod Varghese Sadanandavalli Retnaswami Chandra Rita Christopher Jamuna Rajeswaran Chandrajit Prasad R Subasree Thomas Gregor Issac |
spellingShingle |
Vinod Varghese Sadanandavalli Retnaswami Chandra Rita Christopher Jamuna Rajeswaran Chandrajit Prasad R Subasree Thomas Gregor Issac Cognitive dysfunction and its determinants in patients with neurocysticercosis Indian Journal of Psychological Medicine Cholinesterase levels cognitive dysfunction neurocysticercosis |
author_facet |
Vinod Varghese Sadanandavalli Retnaswami Chandra Rita Christopher Jamuna Rajeswaran Chandrajit Prasad R Subasree Thomas Gregor Issac |
author_sort |
Vinod Varghese |
title |
Cognitive dysfunction and its determinants in patients with neurocysticercosis |
title_short |
Cognitive dysfunction and its determinants in patients with neurocysticercosis |
title_full |
Cognitive dysfunction and its determinants in patients with neurocysticercosis |
title_fullStr |
Cognitive dysfunction and its determinants in patients with neurocysticercosis |
title_full_unstemmed |
Cognitive dysfunction and its determinants in patients with neurocysticercosis |
title_sort |
cognitive dysfunction and its determinants in patients with neurocysticercosis |
publisher |
SAGE Publishing |
series |
Indian Journal of Psychological Medicine |
issn |
0253-7176 |
publishDate |
2016-01-01 |
description |
Introduction: Neurocysticercosis (NCC) is the most common parasitic infection of man. In addition to a headache, seizures, and focal deficits, this is associated with significant cognitive dysfunction. Many studies revealed that the number and location of lesions are not always responsible for cognitive dysfunction. Cholinesterase and pseudocholinesterase are found in the walls of the cysticercus which could contribute to cholinergic depletion and thus cognitive dysfunction. Patients and Methods: A total of 43 patients who presented with NCC were evaluated for cognitive deficits, as well as cholinesterase levels in cerebrospinal fluid (CSF) with control CSF from patients undergoing spinal anesthesia. Blood levels of interleukin-10 and tumor necrosis factor alpha were also estimated and correlated with cognitive deficits. Results: There is a mild increase in the acetylcholinesterase in CSF of patients compared to controls, but it did not correlate with cognitive deficits. There is an increase in interleukins to a significant level which correlates with vesicular stage of the organism and cognitive impairment. The number of lesions also correlated with cognitive impairment even though the location did not. The domains of cognitive deficits seen are sustained attention, category fluency, verbal working memory, planning, set shifting, verbal learning, visual memory, and construction. Discussion and Conclusion: NCC is associated with multi-domain cognitive impairment correlates with vescicular stage, proinflammatory cytokines and number of lesions but not location, vesicular stage, and proinflammatory cytokines. |
topic |
Cholinesterase levels cognitive dysfunction neurocysticercosis |
url |
http://www.ijpm.info/article.asp?issn=0253-7176;year=2016;volume=38;issue=2;spage=142;epage=146;aulast=Varghese |
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