Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis
The paper presents an update on the mechanisms for enhanced hepatic vascular resistance to the portal circulation underlying the pathogenesis of portal hypertension in liver cirrhosis. In addition to gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules...
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"Consilium Medicum" Publishing house
2014-02-01
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Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31471 |
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doaj-0766dcbcb5f740c0ad1c5e3be0ad00752020-11-25T02:38:47Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422014-02-01862909528487Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosisD V GarbuzenkoThe paper presents an update on the mechanisms for enhanced hepatic vascular resistance to the portal circulation underlying the pathogenesis of portal hypertension in liver cirrhosis. In addition to gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules, the morphofunctional rearrangement of the hepatic vasculature is shown to play an important role in this process. It is characterized by endothelial dysfunction and impaired paracrine interaction between activated stellate hepatocytes and sinusoidal endotheliocytes, sinusoidal remodeling and capillarization, as well as intrahepatic angiogenesis.https://ter-arkhiv.ru/0040-3660/article/view/31471liver cirrhosisportal hypertensionpathogenesisendothelial dysfunctionsinusoidal remodelingangiogenesis |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
D V Garbuzenko |
spellingShingle |
D V Garbuzenko Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis Терапевтический архив liver cirrhosis portal hypertension pathogenesis endothelial dysfunction sinusoidal remodeling angiogenesis |
author_facet |
D V Garbuzenko |
author_sort |
D V Garbuzenko |
title |
Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
title_short |
Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
title_full |
Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
title_fullStr |
Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
title_full_unstemmed |
Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
title_sort |
morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2014-02-01 |
description |
The paper presents an update on the mechanisms for enhanced hepatic vascular resistance to the portal circulation underlying the pathogenesis of portal hypertension in liver cirrhosis. In addition to gross hepatic structural disorders related to diffuse fibrosis and formation of regenerative nodules, the morphofunctional rearrangement of the hepatic vasculature is shown to play an important role in this process. It is characterized by endothelial dysfunction and impaired paracrine interaction between activated stellate hepatocytes and sinusoidal endotheliocytes, sinusoidal remodeling and capillarization, as well as intrahepatic angiogenesis. |
topic |
liver cirrhosis portal hypertension pathogenesis endothelial dysfunction sinusoidal remodeling angiogenesis |
url |
https://ter-arkhiv.ru/0040-3660/article/view/31471 |
work_keys_str_mv |
AT dvgarbuzenko morphofunctionalrearrangementofthehepaticvasculatureinthepathogenesisofportalhypertensioninlivercirrhosis |
_version_ |
1724789569171226624 |