Morphological changes of gastric mucosa depending on functional dyspepsia syndrome

• Main Authors: Svintsitskyy A., Korendovych I., Kuryk O., Solovyova G.
• Format: Article
• Language: Russian
• Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2014-06-01
• Series: Морфологія
• Subjects: functional dyspepsia; gastritis; atrophy; metaplasia; dysplasia
• Online Access: http://www.morphology.dp.ua/_pub/MORPHO-2014-08-02/14sasvfd.pdf

Background. Chronic gastritis process of cell renewal in the mucosa is disturbed, leading to rapid movement of the generative cell zone without full differentiation into mature specialized area accommodation epithelial cells. The result of this process is the inability to fully function gastric glands. Crucial in the diagnosis of gastritis given the nature of the morphological changes of the gastric mucosa and preferential localization of these changes. Objective. To assess histological changes of gastric mucosa in patients with clinically different types of functional dyspepsia. Methods. Adult patients (18-65 years) with confirmed diagnosis of functional dyspepsia were eligible to participate. Biopsy specimens were taken from stomach due to the Houston-updated gastric biopsy sampling protocol for the next histological examination. One expert gastrointestinal pathologist assessed all tissue samples. Atrophy was assessed due to Operative Link for Gastritis Assessment (OLGA) staging system. Results. 75 patients were recruited, 42 of which had epigastric pain (I group) and 33 – postprandial distress syndrome (II group) due to Rome III criteria (2006). Antral and corpus atrophy were detected at the same frequency in both groups (p>0.05), however the stage of atrophy didn’t exceed I in all cases. Complete antral metaplasia was revealed in 11 (26.2%) patients of the I group and 11 (33.3%) patients of the II one. Incomplete antral metaplasia was seen in 2 (4.7%) patients of the I group and 2 (6.1%) patients of the II one. No cases of corpus metaplasia or dysplasia were found. Conclusion. Our study didn’t reveal statistically significant correlation between stage of gastritis, atrophic or metaplastic changes and clinical symptoms of functional dyspepsia. Citation: Svintsitskyy A, Korendovych I, Kuryk O, Solovyova G. [Morphological changes of gastric mucosa depending on functional dyspepsia syndrome]. Morphologia. 2014;8(2):50-5. Ukrainian.