Implication of Tumor Necrosis Factor - Alpha in Preeclampsia
Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. Material and Method: A transversal...
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Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca
2008-12-01
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Online Access: | http://ami.info.umfcluj.ro/Full-text/AMI_23_2008/AMI(23)_011_018.pdf |
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doaj-07753095bf0d4a2c9482777b1d88911d2020-11-25T01:26:51ZengIuliu Hatieganu University of Medicine and Pharmacy, Cluj-NapocaApplied Medical Informatics1224-55932008-12-01233-41118Implication of Tumor Necrosis Factor - Alpha in PreeclampsiaDan MIHUNicolae COSTINLigia Daniela BLAGASeptimiu CIUCHINĂRaluca Bogdana POPIntroduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. Material and Method: A transversal study was performed in three groups of patients: non-pregnant patients, patients with normal pregnancies in the third trimester, patients with preeclampsia. Serum TNF-α levels were determined using the immunometric sandwich EIA method.Results: The results obtained confirm a significant increase (p<0.01) in circulating TNF-α levels in the last trimester of pregnancy, compared to the non-pregnant status. Significantly increased serum TNF-α concentrations (p<0.001) were also found in pregnant patients with preeclampsia, compared to normotensive pregnant women. Conclusion: This proinflammatory cytokine can be a potential marker of the severity of the preeclamptic syndrome, without being an indicator of the fetal status at birth.http://ami.info.umfcluj.ro/Full-text/AMI_23_2008/AMI(23)_011_018.pdfPreeclampsiaNormal pregnancyTumor necrosis factor-αProinflammatory state. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dan MIHU Nicolae COSTIN Ligia Daniela BLAGA Septimiu CIUCHINĂ Raluca Bogdana POP |
spellingShingle |
Dan MIHU Nicolae COSTIN Ligia Daniela BLAGA Septimiu CIUCHINĂ Raluca Bogdana POP Implication of Tumor Necrosis Factor - Alpha in Preeclampsia Applied Medical Informatics Preeclampsia Normal pregnancy Tumor necrosis factor-α Proinflammatory state. |
author_facet |
Dan MIHU Nicolae COSTIN Ligia Daniela BLAGA Septimiu CIUCHINĂ Raluca Bogdana POP |
author_sort |
Dan MIHU |
title |
Implication of Tumor Necrosis Factor - Alpha in Preeclampsia |
title_short |
Implication of Tumor Necrosis Factor - Alpha in Preeclampsia |
title_full |
Implication of Tumor Necrosis Factor - Alpha in Preeclampsia |
title_fullStr |
Implication of Tumor Necrosis Factor - Alpha in Preeclampsia |
title_full_unstemmed |
Implication of Tumor Necrosis Factor - Alpha in Preeclampsia |
title_sort |
implication of tumor necrosis factor - alpha in preeclampsia |
publisher |
Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca |
series |
Applied Medical Informatics |
issn |
1224-5593 |
publishDate |
2008-12-01 |
description |
Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of preeclampsia. Material and Method: A transversal study was performed in three groups of patients: non-pregnant patients, patients with normal pregnancies in the third trimester, patients with preeclampsia. Serum TNF-α levels were determined using the immunometric sandwich EIA method.Results: The results obtained confirm a significant increase (p<0.01) in circulating TNF-α levels in the last trimester of pregnancy, compared to the non-pregnant status. Significantly increased serum TNF-α concentrations (p<0.001) were also found in pregnant patients with preeclampsia, compared to normotensive pregnant women. Conclusion: This proinflammatory cytokine can be a potential marker of the severity of the preeclamptic syndrome, without being an indicator of the fetal status at birth. |
topic |
Preeclampsia Normal pregnancy Tumor necrosis factor-α Proinflammatory state. |
url |
http://ami.info.umfcluj.ro/Full-text/AMI_23_2008/AMI(23)_011_018.pdf |
work_keys_str_mv |
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